慢性持续期支气管哮喘患者肺功能及情绪因素相关性分析

Relevance of lung function and state of anxiety/depression in patients with chronic persistent bronchialasthma

目的探讨慢性持续期支气管哮喘（简称哮喘）患者肺功能及情绪因素的相关性。方法选取2015年9月至2017年12月于我院呼吸内科就诊的患者，根据相应的纳入排除标准，209例慢性持续期哮喘患者被纳入本研究，收集患者相关信息，并采用焦虑抑郁量表评估患者状态进行统计分析。结果纳入本研究的209例慢性哮喘患者中，轻度持续性62例，中度持续性88例，重度持续性59例，随着病情的加重，患者焦虑抑郁评分更高（F=1．46，P〈0．05）；209例患者中，心理健康的患者39例，单纯抑郁的患者50例，单纯焦虑的患者52例，抑郁焦虑共存的患者69例，焦虑抑郁共存的患者其肺功能参数相比于心理健康组或单纯焦虑／抑郁组更差（F=1．67，P〈O．05）；此外，汉密尔顿焦虑量表（HAMA）及汉密尔顿抑郁量表（HAMD）评分与肺功能参数之间存在负相关（P〈0．05），第1秒用力呼气容积占预测值百分比与两种量表之间负相关性最强（与HAMA及HAMD的相关系数分别为-0．665、-0．542）。结论慢性持续期哮喘患者其抑郁焦虑状态与其病情之间存在相关性，在临床治疗时应同样关注患者的精神状态以提高哮喘的预后。

Objective To investigate the relevance of lung function and emotional factors in patients with chronic persistent bronchial asthma （asthma）. Methods From September 2015 to December 2017, 209 chronic asthma patients in respriatory medicine department were recriuted into our study by included and excluded criteria. Collect their baseline information and evluate their psychiological state by anixous/ depression scale. Results In these 209 chronic asthma patients, 62 patients were mild, 88 patients were moderate and 59 patients were severe. As patients got worse, their score of anxiety/depression was higher （ F = 1.46, P〈0.05）. In these patients, 39 patients were psychological healthy, 50 patients were depressed, 52 patients were anxious, 69 patients were both depressed and anxious. Compared with other group, parameter of patients with anxiety and depression were worse （F = 1.76, P 〈 0.05）. Additonally, there were negative relationship between score of Hamilton Anxiety Scale （HAMA）/ Hamilton Depression Scale （HAMD） and patientsr lung function, and FEV：%pred had the strongest negative relationship with scores of these two scales （-0. 665 for HAMA and --0.542 for HAMD）. Conclusions There are relationship between severity of chronic asthma patient and anxiety/depression, treatment for asthma should also intervene patients＇ psychological state.