ADRB2基因多态性与支气管哮喘的研究进展

Research progress between β2-adrenergic receptor gene polymorphisms and bronchial asthma

支气管哮喘（简称哮喘）是一种具有异质性的气道慢性炎症性疾病。哮喘患者在哮喘药物的治疗中也表现出明显的异质性。编码β2肾上腺素能受体的ADRB2基因突变可以影响哮喘的易感性、表型和疗效，本文就ADRB2基因多态性与哮喘的研究进展进行综述。

Bronchial asthma （asthma） is a heterogeneous chronic inflammatory airway disease. Asthmatic patients also showed significant heterogeneity in the treatment. The ADRB2 gene encoding beta 2 adrenergic receptor mutations are associated with the asthmatic susceptibility, phenotype and response to medication. This article reviewed the research progress between the ADRB2 gene polymorphisms and asthma.