白术挥发油对代谢综合征大鼠糖脂代谢的影响

Effect of volatile Oil from Atractylodes Macrocephala Koidz on the Glucolipid Metabolism of Metabolic Syndrome in Rats

目的:研究白术挥发油对代谢综合征大鼠糖脂代谢的影响。方法:采用高脂高糖高盐饮食法制备代谢综合征大鼠模型,造模成功后,分别灌胃二甲双胍(100mg/kg)和白术挥发油(100mg/kg和200mg/kg),给药6周后,取大鼠血清,检测甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)和空腹胰岛素(FINS)含量,同时观察白术挥发油对代谢综合征大鼠体重的影响。结果:与模型组相比较,白术挥发油能有效降低代谢综合征大鼠血清中FBG、FINS、TG、TC和LDL-C水平,提高胰岛素敏感性和HDL-C含量。结论:白术挥发油可通过提高胰岛素敏感性,从而改善代谢综合征大鼠的糖脂代谢。

Objective：The aim of our study is to explore the effect of volatile oil from Atractylodes Macroeephala Koidz （VOA） on the glucolipid metabolism of metabolic syndrome in rats. Methods ： We used high-fat diet to establish a rat model of metabolic syndrome. And then the rats were administrated with metformin （100mg/kg） and VOA （100mg/kg and 200mg/kg）, respectively. Six weeks later, the blood samples were collected for the examination of FBG, FINS, TG, TC and LDL-C level. Whafs more, we also determined the effect of VOA on the body weight of rats with metabolic syndrome. Results：Compared to model group, VOA effectively decreased the FBG, FINS,TG, TC and LI）L-C level of rats with metabolic syndrome, and enhanced insulin sensitive and HDL-C level. Conclusion. VOA enhances insulin sensitive to improve glucolipid metabolism of metabolic syndrome in rats.