美沙拉嗪与灌肠联合应用对溃疡性结肠炎患者的临床治疗效果及其对生命质量的影响

Clinical effect of combined treatment with mesalazine and enema on patients with ulcerative colitis and its influence on patients' quality of life

目的探讨美沙拉嗪联合灌肠治疗溃疡性结肠炎患者的临床效果以及其对生命质量的影响。方法选取2016年2月至2018年3月于中国医科大学附属盛京医院辽东湾分院接受治疗的98例溃疡性结肠炎患者作为研究对象,遵照随机数字表法的分配法则,分为对照组(n=49)和观察组(n=49)。给予对照组患者行美沙拉嗪口服治疗,给予观察组患者行美沙拉嗪与龙血竭散灌肠联合治疗,比较两组患者治疗前后炎症因子变化情况、生命质量以及治疗效果。结果在治疗前,两组患者TNF-α、IL-6、CRP以及生理机能、生理职能、躯体疼痛等多项生活质量比较,差异均无统计学意义(均P>0.05);治疗后,观察组患者的上述指标均显著优于对照组,差异均有统计学意义(均P<0.05)。且观察组患者的临床治疗总有效率(91.8%)显著优于对照组(71.4%),差异有统计学意义(P<0.05)。结论对于溃疡性结肠炎患者在临床中选择美沙拉嗪与灌肠联合应用治疗的效果较单用美沙拉嗪治疗效果显著,与此同时还可减轻炎症反应,提高生命质量。

Objective To study the effect of combined treatment with mesalazine and enema in patients with ulcerative colitis and its influence on quality of life. Methods Ninety-eight patients with ulcerative colitis who received treatment in a hospital from February 2016 to March 2018 were selected according to the distribution method of the random number table method and divided into control group （n=49） and observation group （n=49）. The patients in the control group were treated with oral mesalazine.The patients in the observation group were treated with mesalazine and dragon＇s blood dying and enema. The changes of inflammatory factors, quality of life, and treatment effects were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in TNF-α, IL-6, CRP, physiology function, physiological function, body pain and other quality of life between the two groups （P〉0.05）; after treatment, the above indicators in the observation group All were significantly better than the control group, with significant differences （P〈0.05）. The total effective rate of clinical treatment in the observation group （91.8%） was significantly better than that of the control group （71.4%）, and the difference was significant （P〈0.05）. Conclusion The effect of the combination of mesalazine and enema in the treatment of patients with ulcerative colitis is more effective than that of mesalazine alone. At the same time, it can also reduce the inflammatory response, improve the quality of life.