动态流变学评价血栓的力学特性

Evaluation of mechanical properties of thrombus with dynamic rheology

目的探讨真实血栓的力学特性,为介入取栓器械的选择提供生物力学初步依据。方法采用动态流变学法评价手术取栓后离体1 h血栓的流变学特性,剪切速率、频率扫描法检测血栓流变学参数,温度扫描法检测血栓稳定性。结果血栓稳态流变学实验表明,血栓呈剪切变稀的假塑性流体特征,具有一定的弹性和黏度;同时获得血栓流变特征曲线以及拟合曲线,对是否为钙化血栓作出初步判断。结论为介入取栓器械选择提供了生物力学初步判断依据,为血栓物理建模提供了生物力学特性参数,具有一定的参考价值。

Objective To discuss the mechanical properties of true thrombus so as to provide a preliminary biomeehanical basis for the selection of interventional thrombectomy devices. Methods One hour after the thrombus was collected from the body the rheological characteristics of the thrombus in vitro were evaluated by dynamic rheological method. The thrombus rheological parameters were measured by shear rate and frequency scanning method, and the thrombus stability was determined by temperature scanning method. Results Steady state rheology experiment showed that the thrombus carried the characteristics of pseudoplastic fluids with shear thinning and had certain elasticity and viscosity; the characteristic curve of thrombus rheology and fitting curve were simultaneously obtained, and a preliminary judgment as to whether it was a calcified thrombus or not was made. Conclusion This study provides preliminary judgment basis of biomechanics for the selection of interventional thrombectomy devices, and also provides the characteristic parameters of biomechanics for physical modeling of thrombus.