丁苯酞对脑出血合并肺部感染患者神经功能与炎性因子表达的影响

Analysis of the effect of buphthalein on the neurological function and inflammatory factor expression in patients with cerebral hemorrhage combined with pulmonary infection

目的探究丁苯酞对脑出血合并肺部感染患者神经功能及炎性因子表达的影响。方法选取2014年1月-2017年4月医院收治的脑出血合并肺部感染患者192例为研究对象,随机分为研究组和对照组,各96例,对照组采用常规治疗,研究组在对照组的基础上加用丁苯酞注射液治疗。比较两组患者治疗前后的国立卫生研究院卒中量表(NIHSS)评分,检查治疗前后两组患者白细胞介素-2(IL-2)、降钙素基因相关肽(CGRP)、肿瘤坏死因子-α(TNF-α)的水平。结果治疗后,研究组临床疗效优于对照组(P<0.001);治疗后,两组患者NIHSS评分及IL-2、CGRP、TNF-α均降低(P<0.05),且研究组NIHSS为(9.13±4.38)分低于对照组(13.84±6.42)分(P=0.003);研究组IL-2、CGRP、TNF-α分别为(0.47±0.21)ng/ml、(27.13±8.53)ng/L、(4.37±0.05)mg/L低于对照组(P<0.05)。结论丁苯酞治疗脑出血合并肺部感染具有较好的临床疗效,能改善神经功能缺损,抑制炎症,具有一定的临床价值。

OBJECTIVE To investigate the effects of butylphthalide on the neurological function and expression of inflammatory factors in patients with cerebral hemorrhage complicated with pulmonary infection.METHODS A total of 192 cases of cerebral hemorrhage patients with pulmonary infection treated in the hospital during Jan. 2014– Apr 2017 were selected as research subjects,and randomly divided into the experimental group and the control group,with 96 cases in each group.The control group received conventional treatment,whereas the experimental group treated with butyl phthalide injection on the basis of treatment received by the control group.The National institutes of health stroke scale（National Institute of Health stroke scale,NIHSS）scores were compared between the two groups of patients before and after treatment,and the levels of interleukin-2（IL-2）,calcitonin gene related peptide（CGRP）and tumor necrosis factor-α（TNF-α）were examined for the two groups of patients before and after the treatment.RESULTS After treatment,the clinical efficacy of the experimental group was significantly better than that of the control group（P〈0.001）.After treatment,the NIHSS scores of the two groups were significantly decreased（P〈0.05）,and the NIHSS of the experimental group was（9.13±4.38）points,significantly lower than that of the control group（13.84±6.42）points（P=0.003）.After treatment,IL-2,CGRP and TNF-αlevels decreased in both groups（P〈0.05）,and the above indicators in the experimental group were（0.47±0.21）ng/ml,（27.13±8.53）ng/L,（4.37±0.05）mg/L,respectively,which were significantly lower than those of the control group（P〈0.05）.CONCLUSIONButylphthalide has a good clinical effect in the treatment of patients with cerebral hemorrhage complicated with pulmonary infection,significantly improving neurological deficits and inhibiting inflammation,and has certain clinical value.