赖氨酸特异性脱甲基酶2B在胃癌组织表达及临床意义

Expression and significance of lysine - specific histone demethylase 2B in gastric cancer

目的探讨赖氨酸特异性脱甲基酶2B（KDM2B）在胃癌组织中表达及临床病理意义。方法选取有完整随访资料的胃癌组织标本236例，免疫组织化学法检测KDM2B在胃癌组织中的表达，并分析其与临床病理参数及预后的关系。结果KDM2B在胃癌组织中表达增高（58．9％，139／236），显著高于对照胃黏膜（11．4％，4／35）。KDM2B在胃癌组织中表达上调（χ2=25．690，P=0．000），KDM2B阳性表达与患者组织学分型、淋巴结状态、TNM分期和人表皮生长因子受体2（Her-2）表达明显相关（χ2=12．922、6．817、15．089、5．143，P=0．002、0．033、0．001、0．023），KDM2B阳性表达组胃癌患者5年生存率为22．3％，中位生存期为19个月，KDM2B阴性表达组胃癌患者5年生存率为49．5％，中位生存期为66个月[风险比（HR）=2．340，P=0．000]，Cox分析提示KDM2B是一个独立的预后参数。结论KDM2B参与冒痛发年发展．县一个神寺的予面后参斯．

Objective To study the expression and significance of lysine - specific histone dem- ethylase 2B （KDM2B） protein in gastric cancer and its correlation with clinicopatbologic features and prognosis for gastric cancer. Methods The expression of KDM2B protein was detected by the immunohisto- chemical staining. The relationship between the expression of KDM2B and clinicopathologic characteristics in gastric cancer was analyzed byχ2 test and survival analyses were done by the Kaplan - Meier method and Cox regression, and the differences between the curves were tested with the two - tailed log - rank test. Results The positive rate of KDM2B protein was 58.9% in 236 cases of gastric cancer, and 11.4% in the adjacent gastric mucosa （χ2 = 25. 690, P =0.000 ）. The positive rate of KDM2B was correlated with histological classification, lymph node status, TNM stage and human epidermal growth factor receptor -2 （ Her -2） expression （χ2 = 12. 922, 6. 817, 15. 089, 5. 143 ,P = 0. 002, 0. 033, 0. 001, 0. 023, respectively）. The Kaplan - Meier analysis showed KDM2B was associated with poor prognosis [ hazard ratio （HR） =2. 340, P=0. 000]. The 5 - year survival rate of KDM2B positive gastric cancer was 22. 3% , and the median survival time was 19 months. The 5 -year survival rate of KDM2B negative gastric cancer was 49. 5% , and the median survival time was 55 months. Furthermore, Cox stepwise hazard analysis revealed KDM2B was an independent prognostic index for gastric cancer. Conclusion KDM2B was an independent prognostic index for gastric cancer.