补体在酒精性肝病中作用研究进展

The research progress of complement in alcoholic liver disease

酒精性肝病（ALD）是世界范围内慢性肝病的最重要病因之一，随着ALD发病率逐年增长，此病对人类健康的危害日益严重，备受全世界关注。ALD的发病机制非常复杂，目前尚未清楚其确切发病机制。研究证实活化的补体成分参与ALD发病进程，预示通过补体干预改善ALD的新思路，本文就补体在酒精性肝病中的作用及发病机制研究进展做一综述。

Alcoholic liver disease （ALD） is one of the most important causes of chronic liver disease world- wide. With the increasing in the incidence of alcohol - induced liver disease, it has become increasingly hazardous to human health and has been affected globally. The pathogenesis of ALD is very complex and its exact pathogenesis still remains elusive. Studies have been confirming that activated complement components participate in the pathogenesis of ALD, indicating a new strategy for improving ALD through complement intervention. This article reviews the role and mechanism of complement involvement in alcoholic liver disease.