儿童幽门螺杆菌感染性腹痛与食物不耐受的关系探讨

Relationship between Helicobacter pylori infectious bellyache and food intolerance in children

目的：探讨儿童幽门螺杆菌（HP）感染性腹痛与食物不耐受的关系，为临床诊治与预后提供依据。方法：选取2016年1月～2017年12月到我院收治的HP感染性腹痛儿童105例作为观察组，另选取同期100例健康儿童作为对照组，进行血常规、CRP、血沉、血清特异性IgG抗体和肝功能检测，比较两组食物不耐受情况并进行统计学分析。结果：观察组儿童对牛奶、鸡蛋、大豆、虾、螃蟹不耐受比例分为别67．62％、52．38％、28．57％、20．00％，显著高于对照组儿童不耐受比例，差异具有统计学意义（P〈0．05）；观察组儿童食物不耐受1种、2种、3种及以上种类比例分别为13．33％、40．95％、21．90％，显著高于对照组儿童食物不耐受种类，差异具有统计学意义（Z-=5．262，P〈0．05）；HP感染性腹痛儿童食物不耐受相关因素为嗜酸性粒细胞增多、白细胞增多、球蛋白增多、CRP增多。结论：HP感染性腹痛儿童发生食物不耐受的风险增加，嗜酸性粒细胞、白细胞、球蛋白、CRP增多为HP感染性腹痛儿童食物不耐受的高风险因素。

Objective： This study aims to investigate the relationship between Helicobacter pylon （HP） infectious bellyache and food intolerance in children in order to provide evidence for clinical diagnosis and treatment. Methods： 105 children with HP infectious bellyache in our hospital from January in 2016 to December in 2017 were selected as the observation group, and 100 healthy children in the same period as the control group. Blood routine test, CRP, ESR, serum specific IgG antibody and liver function test were performed in two groups. The intolerance of food in the two groups was compared and analyzed statistically. Results： The proportion of children＇s intolerance to milk, eggs, soybean, shrimp and crab was 67.62%, 52.38%, 28.57% and 20% in the observation group, which was significantly higher than that of the control group. The difference was statistically significant （P〈0.05） . The proportion of 1, 2 and 3 kinds of food intolerance in the observation group was 13.33%, 40.95% and 21.90%, which was significantly higher than that of the control group. The difference was statistically significant （Z=-5.262, P〈0.05） . The related factors of food intolerance in children with HP infectious bellyache were eosinophilia, leukocytosis, increased globulin and increased CRP. Conclusion： Risk of food intolerance increased in children with HP infectious bellyache. Increasing eosinophilic material cells, leukocytes, globulin and CRP are high risk factors for food intolerance in children with HP infectious bellyache.