桂枝汤对体温双向调节作用的机理探讨─—对下丘脑神经降压素和促肾上腺皮质激素作用的影响

Mechanism Guixhi Decoction On DualDirectional Thermoregulation:Effect of Neurotensinand ACTH on Hypothermia

神经降压素（ＮＴ）和促肾上腺皮质激素（ＡＣＴＨ）是存在于中枢神经系统内、具有致冷原性质的神经肽。脑室注射［Ｄ－Ｔｙｒ＂］一ＮＴ或ＡＣＴＨ均能引起正常大鼠体温急剧降低。ＮＴ的降体温作用呈剂量依赖型并和周围环境温度有关。于脑室注射前１小时，以桂枝汤１０ｇ生药／Ｋｇ灌胃大鼠，能拮抗［Ｄ—Ｔｙｒ＂］一ＮＴ的降体温作用，但不能拮抗ＡＣＴＨ的降体温效应。实验结果揭示：ＮＴ参与了桂枝汤对体温的双向调节。ＡＣＴＨ的作用尚待进一步工作。

Neurotensin and ACTH are neuropeptids as endogenous cryogensin central nervous system, BOdy temperature was rapidly decreased when[D Tyr'] neurotensin(NT) or ACTH was administered in cerebroventricular injec-tion(icv)in normal rats.The hypothermic action of NT was dose一dependentpattern and related to environmentaI temperature. Oral administration of 10gcrude drug/Kg Guizhi decoction(GZD)one hour before icv of NT could an-tagonize the hypothermia. But this antagonistic effect was not observed in the ex-periment with ACTH treatment.The results indicated that NT was involved inthe mechanism of dual directional thermoregulation by GZD,but the role ofACTH in the thermoregulation was unclear.