血清人附睾分泌蛋白4与糖类抗原125检测对卵巢肿瘤的诊断价值

The clinical value of combined detection of serum human epididymal secretory protein 4 and carbohydrate antigen 125 in the diagnosis of ovarian tumors

目的探讨人附睾分泌蛋白4(HE4)与糖类抗原125(CA125)检测在卵巢肿瘤中的临床诊断价值。方法选取该院2015年3月至2016年8月收治的44例卵巢癌患者纳入卵巢癌组,42例良性卵巢肿瘤患者纳入良性卵巢肿瘤组,同期体检健康者40例纳入对照组,采用酶化学发光法检测所有研究对象血清HE4和CA125水平,并进行比较。结果卵巢癌组血清中HE4和CA125水平明显高于良性卵巢肿瘤组和对照组,差异有统计学意义(P<0.05)。良性卵巢肿瘤组血清中HE4和CA125水平明显高于对照组,差异有统计学意义(P<0.05)。结论 HE4与CA125检测对提高卵巢癌的诊断水平有重大意义,也是评判卵巢癌疗效和预后较为理想的方法。

Objective To investigate the clinical diagnostic value of human epididymal secretory protein 4（HE4）and carbohydrate antigen 125（CA125）in ovarian tumors.Methods A total of 44 patients were collected in ovarian cancer group,42 patients in ovarian benign tumor group,40 healthy subjects in control group from March 2015 to August 2016.Enzyme chemiluminescence method was used to detect serum HE4 and CA125 levels,then compared the two indicators in the three groups.Results The levels of serum HE4 and CA125 in ovarian cancer group were higher than those in benign ovarian tumor group and control group,the differences were significant（P0.05）.The levels of serum HE4 and CA125 in benign ovarian tumor group were higher than those in control group,the differences were significant（P0.05）.Conclusion HE4 and CA125 detection is of great significance to improve the diagnosis of ovarian cancer,and they are also ideal method to evaluate the efficacy and prognosis of ovarian cancer.