影响上皮性卵巢癌复发的高危因素分析

Analysis on the high recurrence risk factors of ovarian cancer

目的探讨上皮性卵巢癌术后复发的危险因素。方法回顾性分析该院2014年6月至2017年2月收治的98例上皮性卵巢癌患者的临床资料,分析年龄、体质量、手术方式、组织分化程度、残留病灶、术前肿瘤标志物表达、术后放化疗方式等因素对卵巢癌术后复发的影响。结果不同年龄、体质量、手术方式、放化疗方式患者复发例数比较,差异无统计学意义(P>0.05)。而有无移动性浊音,不同术前肿瘤标志物表达、组织分化程度、临床分期、淋巴结清除范围患者复发例数比较,差异有统计学意义(P<0.05)。Logistic多因素回归分析显示移动性浊音、肿瘤标志物表达、临床分期、组织分化程度、淋巴结清除范围是影响卵巢癌复发的独立危险因素(P<0.05)。结论术前有腹水、术前及术后肿瘤标志物呈高表达、低分化的晚期上皮性卵巢癌、残余病灶大、淋巴结清除率低是卵巢癌术后复发的高危因素,对此类患者应严密随访,以便更早发现肿瘤复发。

Objective To investigate the high recurrence risk factors of ovarian cancer.Methods The clinical data of 98 patients with epithelial ovarian cancer who were admitted in Hunan Province Maternal and Child Health Care Hospital from June 2014 to February 2017 were retrospectively analyzed.The effect of age,body weight,surgical methods,histological grade,residual lesions,the value of preoperative tumor markers,the method of postoperative radiotherapy and chemotherapy and other factors on the recurrence of ovarian cancer were anlyzed.Results There were no significant difference on the recurrence cases among patients with different age,body weight,surgical methods,the method of postoperative radiotherapy and chemotherapy（P0.05）.There were significant differences on the recurrence cases among patients with different shifting dullness,expression of preoperative tumor markers,clinical stage,histological differentiation and lymph node clearance（P0.05）.All of them were risk factors of postoperative recurrence.Conclusion Preoperative ascites,preoperative and postoperative tumor markers significantly increased,poorly differentiated advanced epithelial ovarian cancer,residual lesions,lymph node clearance are high risk factors of recurrence of ovarian cancer,patients with these risk factors should be closely followed in order to detect tumor recurrence earlier.