慢性心力衰竭患者血清MMP-2、9水平及意义

The Levels and Significance of Serum Matrix Metalloproteinases-2,9 in Patients with Chronic Heart Failure

目的:通过检测慢性心力衰竭患者(chronic heart failure,CHF)血清基质金属蛋白酶2、9(matrix metalloproteinases-2,9,MMP-2,9)水平,从而协助评价患者心功能状况。方法:2015年1月-2017年11月在笔者所在医院住院诊断为慢性心功能衰竭患者214例,并按照NYHA心功能分级分为Ⅰ～Ⅳ级,对照组选择同期健康体检者207例,同时行血清MMP-2、9及心脏彩超检查。结果:慢性心力衰竭患者的血清MMP-2、9较对照组明显升高(P<0.05),且不同NYHA心功能分级患者血清MMP-2、9水平差异有统计学意义(P<0.05)。结论:通过检测MMP-2、9可协助评价心功能衰竭严重程度。

Objective：To evaluate the cardiac function of patients by detecting the serum levels of matrix metalloproteinase 2 and 9.Method：214 cases diagnosed as heart failure in our hospital were included from January 2015 to November 2017.These patients were divided into Ⅰ-Ⅳ grades according to the NYHA cardiac function classification.207 healthy people were set as the control group.The serum matrix metalloproteinases-2,9 measure and cardiac color Doppler examination were performed in both two groups.Result：The serum matrix metalloproteinases-2,9 in the patients with chronic heart failure were significantly higher than those in the control group（P〈0.05）,and there was significant difference in serum matrix metalloproteinases-2,9 levels among different NYHA cardiac function classification（P〈0.05）.Conclusion：The detection of serum matrix metalloproteinases-2,9 can be used to evaluate the severity of heart failure.