双环醇联合异甘草酸镁治疗甲亢性肝损害的疗效观察

Effect observation of combination of bicyclol tablets and magnesium isoglycyrrhizinate injection on liver function abnormality induced by hyperthyroidism

目的探讨双环醇联合异甘草酸镁治疗甲亢性肝损害的疗效观察。方法 60例甲亢性肝损害患者随机分为观察组和对照组,每组30例,观察组应用异甘草酸镁联合双环醇,治疗组单用异甘草酸镁,治疗1周后进行疗效及不良反应评价。结果两组治疗前总胆红素(TBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)组间比较差异均无统计学意义(P>0.05),治疗后两组肝功能指标(TBIL、ALT、AST)均较治疗前显著下降(P<0.05),且两组间比较观察组疗效优于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论采用双环醇联合异甘草酸镁的治疗方案安全、有效,应进行临床推广。

Objective To abserve effects of combination of Bicyclol tablets and magnesium isoglycyrrhizinate injection on liver function abnormality induced by hyperthyroidism.Methods 60 cases of liver function abnormality induced by hyperthyroidism were randomly divided into the observation group and the control group,with 30 cases in each group.Both groups were administered with magnesium isoglycyrrhizinate injection,bicyclol tablets were given to the observation group in addition.The therapeutic efficacy and adverse reactions were evaluated after 1-week therapy.Results There is no statistics significance among factors such as TBIL,ALT and AST before treatment between the two groups（P〉0.05）.The level of liver function indexes such as TBIL,ALT and AST decreased in both groups（P〈0.05）.The decreases of these factors of the observation group were better than those in the control group and there was statistical significance between the two groups（P〈0.05）.There was no statistical significance in adverse reactions between the two groups（P〉0.05）.Conclusion The combined therapy of bicyclol tablets and magnesium Isoglycyrrhizinate injection was safe and effective and can be promoted in clinical practice.