大剂量丙种球蛋白联合美罗培南治疗41例新生儿败血症患儿的疗效分析

Curative effect analysis of large doses of gamma globulin combined with meropenem in the treatment of 41 neonatal sepsis patients

目的探讨大剂量丙种球蛋白联合美罗培南治疗新生儿败血症的临床疗效。方法选取某院2016年3月至2017年11月新生儿败血症患儿82例,随机数表法分为研究组(n=41)与对照组(n=41)。常规治疗基础上对照组采用美罗培南(持续治疗7 d)治疗,研究组于对照组基础上加用大剂量丙种球蛋白(连续治疗3 d)治疗。统计两组症状改善(神经系统症状、拒奶、体温)与住院时间、临床疗效。结果研究组神经系统症状、拒奶及体温改善时间、住院时间短于对照组(P<0.05);研究组总有效率(92.68%)高于对照组(73.17%),P<0.05。结论采取大剂量丙种球蛋白联合美罗培南治疗新生儿败血症,可缩短患儿症状改善及住院时间,提高治疗效果。

Objective To explore the clinical curative effect of large doses of gamma globulin combined with meropenem in the treatment of neonatal sepsis.Methods 82 cases of newborn infants with sepsis admitted in a hospital from March,2016 to November,2017 were selected and randomly divided into the research group and the control group,with 41cases in each group.Besides conventional treatment,the control group was given meropenem（treatment consecutively for 7 days） while the research group was given meropenem and large doses of gamma globulin（treatment consecutively for 3 days）.The improvement of symptoms（nervous system symptoms,milk refusal and temperature）,hospital stays and clinical curative effect of the two groups were compared.Results The improvement time of nervous system symptoms,milk refusal,and temperature and hospital stays of the research group were shorter than those of the control group and the difference showed statistical significance（P〈0.05）.The total effective rate of the research group was 92.68%,higher than that（73.17%） of the control group and the difference was of statistical significance（P〈0.05）.Conclusion The combination of large doses of gamma globulin with meropenem in the treatment of neonatal sepsis could shorten the symptoms and hospital stays of newborn patients and improve curative effect.