协日嘎三味散对口腔扁平苔藓组织中TNF-α和IL-6表达的影响

Impact of Xieriga Sanweisan on Expression of Tumor Necrosis Factor-α and Interleukin-6 in Patients with Oral Lichen Planus

目的探讨协日嘎三味散对口腔扁平苔藓(OLP)患者中肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6水平调节作用,为临床用药提供理论依据。方法 60例OLP患者随机分为2组,分别给予协日嘎三味散和雷公藤总甙片进行治疗,采用双抗体夹心法检测了治疗前后TNF-α和IL-6水平的变化。结果治疗8周后协日嘎三味散对口腔扁平苔藓(OLP)患者的黏膜斑纹改善方面和TNF-α、IL-6水平调节作用明显优于雷公藤总甙片;结果显示患者黏膜充血及白色斑纹程度越重,TNF-α、IL-6的水平就越高。结论口腔扁平苔藓患者因病情不同免疫平衡失调的严重程度也不同;协日嘎三味散是治疗OLP有效并具有调节免疫功能的药物,值得临床推广应用。

Objective In order to investigate the regulatory effect of Xieriga Sanweisan on TNF-α and IL-6 of patients with oral lichen planus（OLP） to provide basic theoretical data for clinical medication. Methods Sixty patients with OLP were randomly divided into two groups respectively, treated with Xieriga sanweisan and multi-glycosidic tablets of Tripterygium wilfordii. The changes of TNF-α and IL-6 were tested before and after treatment by double-antibody sandwich method. Results Eight weeks later, Xieriga Sanweisan was much better than multi-glycosidic tablets of Tripterygium wilfordii in improvement of mucous patch and regulation of TNF-α and IL-6 in patients with oral lichen planus. The more severe hyeremia and white patch were, the higher TNF-α and IL-6 were. Conclusion For patients with oral lichen planus, the degree of immunological imbalance will vary according to the different condition of patients. Xieriga Sanweisan is quite effective in treatment of OLP and regulation of immunologic function, so they will be deserved to clinical popularization and application.