摘要
目的探讨干细胞转录因子SOX2在喉鳞癌组织中的表达情况,分析其表达与预后的关系。方法采用流式细胞术检测45例患者喉鳞癌组织中的SOX2的表达情况,并结合患者3年以上随访资料,分析其表达与预后的关系。结果干细胞转录因子SOX2的表达水平与喉鳞癌患者的总生存期呈负相关,是影响喉鳞癌预后的独立因素,其相对风险度为5.86。结论干细胞转录因子SOX2在喉鳞癌组织中的表达明显高于在喉部正常组织中的表达,且其表达水平是影响喉鳞癌预后的独立因素。
Objective To investigate the expression of SOX2 in laryngeal carcinoma and analyze the relation of SOX2 and prognosis. Methods We measured the expression of SOX2 in 45 laryngeal carcinoma fresh samples by flow cytometere（Epics-XL Ⅱ）,The correlation between the prognosis and SOX2 expression in laryngeal squamous cancer was analyzed. Results The analysis showed that higher SOX2 expression was significantly associated with poorer overall survival. SOX2 expression level was an independent factor affecting the prognosis of laryngeal squamous cell carcinoma and the relative risk was 5.86. Conclusion The expression 1 evel of stem cell transcription factor SOX2 in laryngeal squamous cell carcinoma is significantly higher than that of normal laryngeal tissue,which makes SOX2 an independent prognostic factor of survival.
作者
叶飞
傅敏仪
陈国平
Ye Fei, Fu Minyi, Chen Cruoping(Department of Otolaryngology Head and Neck Surgery, Zhongshan Hospital Affiliated of SUN Yat-sen Uniwersity, the People＇s HospitalofZhongshan, Zhongshan, Guangdong, 528403, China)
出处
《中国医学文摘（耳鼻咽喉科学）》
2018年第5期361-364,共4页
Chinese Medical Digest(Otorhinolaryngology)
基金
中山市科技局科研项目(2014A1FC083)
关键词
喉鳞癌
SOX2
预后
Laryngeal Squamous Cell Carcinoma
SOX2
Prognosis
