帕金森病淡漠解剖学及神经生化学机制

Anatomical and neurochemical mechanisms of apathy in Parkinson's disease

淡漠系动机减少导致目标导向动作减少的综合征,是帕金森病常见的非运动症状。帕金森病淡漠的发生机制尚未阐明,主流观点认为是前额叶-基底神经节环路损害所致,不同区域前额叶-基底神经节环路损害导致不同类型淡漠,其机制与基底神经节及相关皮质区域的解剖学和神经生化学密切相关。

Apathy is one of the common non-motor symptoms（NMS） in Parkinson＇s disease（PD）,which can be defined as a syndrome of decreased motivation that manifests as a decrease in goal-directed behaviors. The mechanism of apathy in PD is undetermined, however, the mainstream opinion is that apathy is caused by prefrontal cortex-basal ganglia circuits damage. Prefrontal cortex-basal ganglia circuits damage in different regions lead to different subtypes of apathy, and the mechanism is associated with the anatomy and neurochemical of basal ganglia and related cortical regions.