卡培他滨联合奥沙利铂治疗进展期胃癌26例的中期随访研究

The mid - term follow - up study of capecitabine combined with oxaliplatin in the treatment of 26 patients with advanced gastric cancer

目的 通过对卡培他滨联合奥沙利铂（XELOX）治疗进展期胃癌患者的中期随访,探讨其临床疗效以及生存情况.方法 选取山西医科大学第二医院西院2014年5月至2016年5月收治的进展期胃癌患者52例,采用随机数字表法分为对照组（n=26）与研究组（n=26）.对照组采用奥沙利铂联合亚叶酸钙、氟尿嘧啶（FOLFOX）化疗方案,研究组采用XELOX化疗方案,均治疗3个周期.疗程结束后比较两组临床疗效、治疗前后血清胃泌素-17（GAS-17）水平以及两组生存情况.结果 研究组治疗有效率（76.92％）显著高于对照组（50.00％）（χ^2=4.064,P〈0.05）;疗程结束后两组血清GAS-17水平较治疗前降低,且研究组低于对照组（t=7.399,P〈0.05）;研究组中位无进展生存期（9.3个月）、中位总生存期（12.6个月）均长于对照组（均P〈0.05）.结论 采取XELOX化疗方案治疗进展期胃癌,可有效降低血清GAS-17水平,提高治疗效果,延长患者生存期限.

Objective To investigate the effect of XELOX chemotherapy protocols on the prognosis of patients with advanced gastric cancer .Methods From May 2014 to May 2016,a total of 52 patients with advanced gastric cancer in the Western Branch of the Second Hospital of Shanxi Medical University were selected and divided into control group and study group according to the random number table , with 26 cases in each group .The control group was treated with the FOLFOX chemotherapy protocols , and the study group was treated with the XELOX chemotherapy protocols.All the patients were treated for 3 cycles.After treatment,the clinical efficacy and serum gastrin-17 （GAS-17） levels before and after treatment of the two groups were statistically analyzed .At the end of the treatment and following up until now ,the survival rate of the two groups was statistically analyzed .Results The effective rate of the study group （76.92%） was significantly higher than that of the control group （50.00%）（χ^2=4.064,P〈0.05）.After treatment,the serum level of GAS -17 of the two groups decreased compared with before treatment,and which of the study group was lower than that of the control group （t=7.399,P〈0.05）.The median progression free survival （9.3 months） and median total survival （12.6 months） in the study group were longer than those in the control group（all P〈0.05）.Conclusion XELOX chemotherapy in the treatment of advanced gastric cancer can effectively reduce the level of serum GAS -17 ,improve the therapeutic effect and prolong the duration of life of the patients .