甲状腺功能水平与稽留流产关系的研究

Study on the relationship between thyroid function and missed abortion

目的:探讨甲状腺功能水平与稽留流产的关系。方法:选择郑州大学附属洛阳中心医院门诊部经两家医院联合诊断的146例稽留流产患者作为观察组,另随机选择146例同期内行早期人工流产的正常女性作为对照组,测定两组患者的甲状腺功能水平,并进行对比分析。结果:观察组女性的游离甲状腺素(FT4)低于对照组,促甲状腺激素(TSH)和甲状腺过氧化物酶抗体(TPOAb)阳性发生率均高于对照组,差异有统计学意义(P <0. 05)。结论:甲状腺激素参与早期胚胎的形成和发育,对维持正常妊娠非常重要。甲状腺功能减退和TPOAb阳性与稽留流产关系密切,可能是导致稽留流产的重要原因。

Objective：To investigate the relationship between thyroid function level and delayed abortion. Methods：All 146 cases of missed abortion diagnosed by two hospitals in the outpatient department of hospital were taken as the research group, also 146 normal women who underwent early abortion in hospital were randomly selected as control group, measurementing their thyroid function levels and carrying out their comparative analysis and study. Results：The free thyroid hormone （FT4 ） of women in the study group was significantly lower than that of the normal control group, also thyroid stimulating hormone （TSH） and the positive rates of thyroid peroxidase antibody （TPOAb） were significantly higher than that in the control group （ P 〈 0.05 ）. Conclusion ： Thyroid hormones is very important for the maintenance of normal pregnancy and participating in the formation and development of early embryos. Hypothyroidism and TPOAb positive are closely related to missed abortion and may be an important cause of abortion.