布地奈德联合硫酸特布他林雾化吸入治疗小儿肺炎的疗效及安全性分析

Efficacy and safety of budesonide combined with terbutaline sulfate in the treatment of children with pneumonia

目的:探讨布地奈德联合硫酸特布他林雾化吸入治疗小儿肺炎的临床效果。方法:选取2016年1月—2017年9月收治的40例小儿肺炎患者,随机分为观察组与对照组,每组20例。对照组采用常规治疗,观察组在对照组的基础上加用布地奈德联合硫酸特布他林雾化吸入治疗,对比分析两组患者疗效。结果:观察组治疗有效率为95%,对照组75%,两组比较,差异有统计学意义(P <0. 05)。治疗前,两组患儿咳嗽评分、喘息评分比较,差异无统计学意义(P> 0. 05);治疗后观察组咳嗽评分、喘息评分明显优于对照组,差异有统计学意义(P <0. 05)。观察组咳嗽消失、喘憋消失、湿啰音消失时间、体温恢复正常时间、住院时间均明显短于对照组(P <0. 05)。治疗前两组患儿C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)比较,差异无统计学意义(P> 0. 05);治疗后观察组患儿CRP、IL-6、TNF-a水平明显低于对照组,两组比较,差异有统计学意义(P <0. 05)。不良反应发生率观察组为10%,对照组为10%,两组比较,差异无统计学意义(P> 0. 05)。结论:布地奈德联合硫酸特布他林雾化吸入治疗小儿肺炎能明显提高疗效,更迅速改善患儿症状,改善炎性因子水平,且安全性高。

Objective ：To investigate the clinical effect of budesonide combined with terbutaline sulfate in the treatment of children with pneumonia. Methods ： Forty patients with pediatric pneumonia admitted from January 2016 to September 2017 were randomly divided into observation group and control group. The control group was treated with conventional therapy. The observation group was treated with budesonide combined with terbutaline sulfate inhalation on the basis of the control group. The efficacy of the two groups was compared. Results：The effective rate was 95% in the observation group and 75% in the control group. The difference between the two groups was statistically significant （ P 〈 0.05 ）. Before treatment, there was no significant difference in cough score and wheezing score between the two groups （P 〉 0.05）. After treatment, the cough score and wheezing score of the observation group were significantly better than the control group, and the difference was statistically significant （ P 〈 0.05 ）. In the observation group, cough disappeared,wheezing disappeared,wet rales and arpeggio disappeared, body temperature returned to normal time, and hospital stay was significantly shorter than the control group （ P 〈 0.05 ）. There were no significant differences in C -reactive protein （CIIP） ,interleukin -6 （IL -6） and tumor necrosis factor （TNF -α） between the two groups before treatment （ P 〉 0.05 ）. The levels of CRP, IL - 6 and TNF - a in the children were significantly lower than those in the control group. The difference was statistically significant （ P 〈 0.05 ）. The incidence of adverse reactions was 10% in the observation group and 10% in the control group. The difference was not statistically significant （P 〉 0.05）. Conclusion：Budesonide combined with terbutaline sulfate inhalation for children with pneumonia can significantly improve the efficacy, more quickly improve the symptoms of children,improve the level of inflammatory factors, and high safety.