分析别嘌呤醇在治疗痛风性肾病中的应用效果及其对血肌酐、尿素氮水平的影响情况

Analysis on the Effect of Allopurinol on the Treatment of Gouty Nephropathy and Its Effect on Serum Creatinine and Urea Nitrogen Levels

目的探讨观察别嘌呤醇在治疗痛风性肾病中的应用效果及其对血肌酐、尿素氮水平的影响情况。方法方便收集2017年1月—2018年3月该院痛风性肾病患者100例,随机分为50例对照组与50例研究组。两组患者入院后常规治疗方案相同,如饮食指导、纠正酸中毒、水电解质紊乱、有高血压患者给予氨氯地平降压,研究组加用别嘌呤醇治疗。对比研究组和对照组治疗前后尿酸水平;研究组和对照组治疗前后血肌酐、尿素氮水平;研究组和对照组治疗前后血压水平;两组痛风性肾病治疗疗效。结果研究组和对照组治疗前尿酸水平分别为(576.38±18.29)mmol/L、(580.13±19.01)mmol/L,比较差异无统计学意义(t=0.17,P>0.05);研究组和对照组治疗后尿酸水平分别为(346.28±7.52)mmol/L、(412.25±9.88)mmol/L,比较差异有统计学意义(t=8.51,P<0.05);研究组和对照组治疗前血肌酐、尿素氮水平分别为[(148.25±26.38)μmol/L、(10.76±2.69)mmol/L]、(145.37±27.15)μmol/L、(10.91±2.57)mmol/L]比较差异无统计学意义(t=0.24、0.15,P>0.05);研究组和对照组治疗后血肌酐、尿素氮水平分别为[(85.26±13.24)μmol/L、(5.13±1.12)mmol/L]、[(129.35±17.19)μmol/L、8.69±2.47)mmol/L],比较差异有统计学意义(t=6.82、7.12,P<0.05);两组痛风性肾病治疗疗效分别为94%、84%,比较差异有统计学意义(P<0.05)。结论别嘌呤醇可以降低痛风性肾病患者尿酸、血肌酐、尿素氮水平,同时对控制患者的血压水平有积极的作用。

Objective This paper tries to investigate the effect of allopurinol on the treatment of gouty nephropathy and its effect on serum creatinine and urea nitrogen levels. Methods Convenient select one hundred patients with gouty nephropathy in the hospital from January 2017 to March 2018 were randomly divided into 50 cases in the control group and 50 cases in the study group. The two groups of patients had the same conventional treatment plan after admission, such as diet guidance, correction of acidosis, water and electrolyte disorders, and patients with hypertension were given amlodipine blood pressure, and the study group was treated with allopurinol. The uric acid levels before and after treatment in the study group and the control group; the levels of seruln creatinine and urea nitrogen before and after treatment in the study group and the control group; the blood pressure levels before and after treatment in the study group and the control group; and the therapeutic effects of gouty nephropathy in the two groups were compared. Results The uric acid levels in the study group and the control group were （576.38±18.29）mmol/L and （580.13±19.01）mmol/L, respectively, the difference was not statistically signficant（t=0.17, P〉0.05）. The uric acid levels in the study group and the control group were respectively （346.28±7.52）mmol/L and （412.25±9.88）mmol/L,the difference was statistically signficant（t=8.51, P〈0.05）. The levels of serum creatinine and urea nitrogen in the study group and control group were [（148.25±26.38）μmol/L, （10.76±2.69）mmol/L], [（145.37±27.15）μmol/L, 10.91＋2.57）mmol/L], the difference was not statistically signficant （t=0.24, 0.15, P〉0.05）; blood creatinine and urea nitrogen after treatment in the study group and control group were [（85.26±13.24）μmol/L, （5.13±1.12）mmol/L, [（129.35±17.19）μmol/ L, （8.69±2.47）mmol/L], and the difference was statistically signficant（t=6.82, 7.12, P〈0.05）; The therapeutic effects of gouty nephropathy were 94% and 84%, respectively, and the difference was statistically signficant（P〈0.05）. Conclusion Allopuri-nol can reduce the levels of uric acid, serum creatinine and urea nitrogen in patients with gouty nephropathy, and has a positive effect on controlling blood pressure levels in patients.