抑郁症患者治疗前后血清超敏C反应蛋白水平变化及其对抗抑郁药物疗效的预测作用

Changes of Serum High-sensitivity C-reactive Protein Levels in Patients with Depression before and after Treatment and Predictive Effect of Antidepressant Drugs

目的分析抑郁症患者治疗前后血清超敏C反应蛋白水平变化及其对抗抑郁药物疗效的预测作用。方法方便选取2016年5月—2018年2月收治的120例抑郁症作为研究对象,按是否伴有躯体症状分为观察组和对照组,另取60名健康人士作为正常组。对照组给以舍曲林治疗,观察组给以度洛西汀治疗。比较治疗前后患者血清基线hs-CRP水平及抑郁严重程度。结果治疗前,对照组(5.68±3.36)和观察组(5.71±3.41)的血清基线hs-CRP水平差异无统计学意义(t=0.049,P>0.05)。治疗8周后,两组患者血清基线hs-CRP水平均明显下降,仍高于健康组hs-CRP水平(2.04±1.35),观察组下降幅度大于对照组,差异有统计学意义(t=2.346,P<0.05);治疗前,对照组(32.17±3.22)分和观察组(31.93±3.45)分的HAMD-24评分差异无统计学意义(t=0.339,P>0.05);治疗8周后,观察组患者的HAMD-24评分(15.13±3.36)分明显低于对照组评分(19.59±4.08)分,差异有统计学意义(t=6.536,P<0.05)。结论通过施药物治疗,有效降低患者血清的hs-CRP水平、HAMD-24评分,缓解患者的抑郁情绪,且度洛西汀治疗效果优于舍曲林。

Objective To analyze the changes of serum high-sensitivity C-reactive protein levels before and after treatment in patients with depression and the predictive effect of antidepressant drugs. Methods 120 cases of depression admitted from May 2016 to February 2018 were conveniently studied. The patients were divided into observation group and control group according to whether they were accompanied by physical symptoms. 60 healthy people were taken as normal group. The control group was treated with sertraline and the observation group was treated with duloxetine. Serum baseline hs-CRP levels and severity of depression were compared before and after treatment. Results Before treatment, there was no signifi cant difference in serum hs-CRP levels between the control group （5.68±3.36） and the observation group （5.71±3.41） （t= 0.049, P〉0.05）. After 8 weeks of treatment, serum hs-CRP levels in the two groups were significantly lower than those in the healthy group （2.04±1.35）, and the decrease in the observation group was greater than that in the control group （t=2.346, P〈 0.05）; There was no significant difference in HAMD-24 scores between the control group （32.17±3.22）points and the observation group （31.93±3.45）points before treatment （t=0.339,P〉0.05）; after 8 weeks of treatment, the HAMD-24 score （15.13±3.36）points was significantly lower in the observation group than in the control group （19.59±4.08）points, and the difference was statistically significant （t=6.536, P〈0.05）. Conclusion By administering drugs, the serum hs-CRP level and HAMD-24 scores are effectively reduced, and the depression of patients is relieved. The effect of duloxetine is better than that of sertraline.