5种血清肿瘤标志物检测在肺癌临床诊断中的意义

Significance of Detection of Five Serum Tumor Markers in Clinical Diagnosis of Lung Cancer

目的研究5种血清肿瘤标志物在肺癌患者诊断中的临床价值。方法方便选择该院2017年1月—2018年1月纳入的80例肺癌患者作为研究组,另选择同期来该院体检的80例良性肺疾病患者作为对照组,所有患者均进行血清CEA、CYFRA21-1、NSE、CA125以及CA242检测,对比两组检测结果。结果研究组血清CEA(52.8±11.3)ng/mL、CYFRA21-1(15.3±5.0)ng/mL、NSE(22.1±7.2)ng/mL、CA125(140.7±13.5)IU/mL以及CA242(37.4±9.7)IU/mL水平均高于对照组(4.6±1.5)ng/mL、(2.8±0.9)ng/mL、(7.2±2.3)ng/mL、(24.2±6.7)IU/mL以及(7.6±2.5)IU/mL,差异有统计学意义(t=37.820, 22.007,17.632,69.139,26.609,P<0.05);不同病理类型患者的5种学血清标志物的检测结果的敏感性差异有统计学意义(χ2=6.132,7.785,7.187,7.064,7.604,P<0.05);5种血清肿瘤标志物联合检测的敏感性93.46%及准确率90.15%高于单一检测的敏感性58.34%、47.65%、60.71%、58.25%、62.83%及准确率68.45%、60.23%、70.64%、65.93%、68.82%,差异有统计学意义(P<0.05)。结论血清肿瘤标志物在肺癌患者诊断中具有重要意义,联合检测可明显提高诊断的准确性及敏感性,值得临床推广及应用。

Objective To study the clinical value of five serum tumor markers in the diagnosis of lung cancer patients. Methods Eighty patients with lung cancer who were included in the hospital from January 2017 to January 2018 were convenient enrolled as the study group. Eighty patients with benign lung disease who were admitted to the hospital for the same period of time were selected as the control group. All patients underwent serum CEA and CYFRA21-1, NSE, CA125 and CA242 tests, comparing the two groups of test results. Results The study group serum CEA （52.8±11.3） ng/mL, CYFRA21-1 （15.3±5.0） ng/mL, NSE （22.1±7.2） ng/mL, CA125 （140.7±13.5） IU/mL and CA242 （37.4± 9.7） IU/mL water was higher than the control group （4.6±1.5） ng/mL, （2.8±0.9） ng/mL, （7.2±2.3） ng/mL, （24.2±6.7） IU/mL and （7.6± 2.5） IU/mL （t= 37.820, 22.007, 17.632, 69.139, 26.609, P〈0.05）; the sensitivity of the detection results of the five serum markers of patients with different pathological types was significantly different （X^2=6.132, 7.785, 7.187,7.064,7.604, P〈0.05）; the sensitivity of the combined detection of five serum tumor markers was 93.46% and the accuracy rate was 90.15% higher than the sensitivity of single detection： 58.34%, 47.65%, 60.71%, 58.25%, 62.83% and the accuracy rate was 68.45%, 60.23%, 70.64%, 65.93%, 68.82%, the difference was statistically significant（P〈0.05）. Conclusion Serum tumor markers are of great significance in the diagnosis of lung cancer patients. Combined detection can significantly improve the accuracy and sensitivity of diagnosis, and it is worthy of clinical promotion and application.