鼠神经生长因子联合神经节苷脂对脑损伤患者神经功能修复的影响

Efficiency of mouse nerve growth factor combined with ganglioside in treatment of patients with brain injury

目的探讨鼠神经生长因子联合神经节苷脂对脑损伤患者神经功能修复的影响。方法将90例颅脑脑损伤患者采用随机数字表法分为A组、B组、C组,每组30例。在常规治疗基础上,A组患者加用神经节苷脂治疗,B组患者加用鼠神经生长因子治疗,C组患者加用神经节苷脂联合鼠神经生长因子治疗。比较3组患者的临床疗效、神经功能评分、日常生活能力评分及肌力评分。结果 C组患者的总有效率为93.33%,高于A、B组(P<0.05),而A组与B组的总有效率比较无统计学差异(P>0.05);3组患者治疗后的神经功能评分、日常生活能力评分、肌力评分均较治疗前显著增高(均P<0.05);C组患者治疗后神经功能评分、日常生活能力评分、肌力评分均高于A、B组(均P<0.05),A组与B组比较无统计学差异(P>0.05)。结论采用神经节苷脂、鼠神经生长因子联合治疗脑损伤患者的临床疗效显著,不仅可有效修复患者的神经功能及受损的肌力,还能提高其日常生活能力,可推广应用于临床。

Objective To investigate the efficacy of mouse nerve growth factor combined with ganglioside in treatment ofpatients with brain injury. Methods Ninety patients with brain injury patients admitted from January 2016 to June 2017 wererandomly assigned in three groups with 30 patients in each group. All patients were treated with conventional therapy; inaddition, patients in group A also received ganglioside, patients in group B received mouse nerve growth factor and patientsin group C received ganglioside plus mouse nerve growth factor. The clinical efficacy was evaluated with the neurologicalfunction score, ADL score and muscle strength score before and after treatment in three groups. Results The overalleffective rate of group C （93.33%） was higher than that of group A and group B （P〈0.05）, while there was no significant differencein effective rate between group A and group B （P〉0.05）. The neurological function score, ADL score and muscle strength scoreswere significantly improved after treatment in all three groups （P〈0.05）; the scores in group C were higher than those of other twogroups （P〈0.05）, however, there was no significant difference between groups A and B （P〉0.05）. Conclusion Gangliosidecombined with mouse nerve growth can more effectively improve nerve function than use of single drug in treatment of patientswith brain Injury.