结直肠癌与肿瘤能量代谢谷氨酰胺旁路途径调控进展研究

Research progress in regulation of glutamine metabolism pathway in colorectal cancer

Warburg效应是大多数肿瘤细胞能量代谢主要途径。谷氨酰胺参与肿瘤细胞另一代谢方式,不仅为其代谢提供氮源和碳源,而且对肿瘤细胞氧化还原稳态、信号转导起重要作用。在肿瘤细胞的谷氨酰胺代谢调控中,需要限速酶或关键酶的参与。近年研究表明,多种因子在不同水平通过影响关键酶或限速酶来调控结直肠肿瘤细胞的谷氨酰胺代谢,为结直肠癌的研究和临床治疗提供重要参考。

Warburg effect is the main pathway of energy metabolism in most tumor cells. Glutamine take part in the another type of cancer energy metabolism by not only providing nitrogen and carbon sources for their metabolism, but also playing an important role in redox homeostasis and signal transduction of tumor cell. In energy metabolism regulation of cancer, rate-limiting enzyme and key enzymes are really indispens- able. Recent studies have shown that many factors regulate the metabolism of glutamine in colorectal cancer cells by affecting key enzymes or rate-limiting enzymes at different levels, providing important references for the research and clinical treatment of＇ colorectal cancer.