口服碳酸钙激活钙敏感受体,改善直肠癌前切除术后控便功能的初步研究

Oral calcium carbonate on the anal function after low anterior rectal cancer resection

目的明确口服碳酸钙激活钙敏感受体,改善直肠癌前切除术后控便功能的疗效。对象和方法收集2017年3月至6月,在中山大学附属第一医院诊治的腹腔镜直肠癌Dixon手术的患者32名,随机分为钙治疗组和对照组,钙治疗组在术后1周起,每天口服碳酸钙1200 mg。手术后第3个月、第6个月评价肛门功能和钙相关并发症。结果术后3个月,钙治疗组的日平均便次、夜间排便率、便后1小时再排便率优于对照组,术后6个月,钙治疗组的日平均便次、夜间排便率、便后1小时再排便率和Wexner评分优于对照组。两组均未见高钙血症和新发泌尿系结石。结论口服碳酸钙激活钙敏感受体,可改善直肠癌前切除术后控便功能,安全有效。

Objective To determine the improvement of oral calcium carbonate on the anal function after low anterior rectal cancer resection by the activation of calcium-sensing receptors. Subjects and meth- ods Thirty-two patients undergone laparoscopic Dixon surgery for rectal cancer in the First Affiliated Hos- pital of Sun Yat-sen University were randomly divided into a calcium treatment group and a control group. Daily oral intake of calcium carbonate 1200 mg was prescribed to the calcium treatment group 1 week after surgery. Assessment of anal function and calcium-related complications was performed in 3 months and 6 months after surgery. Results in 3 months after operation, daily defecation frequency, nighttime defecation rate and 1-hour re-defecation rate were better in the calcium treatment group than in the control group. In 6 months after operation, daily defecation frequency, nighttime defecation rate and 1-hour re-defecation rate and Wexner score were better in the calcium treatment group. No hypercalcemia and new urinary stones were found in both groups. Conclusion The anal ruction after low anterior rectal cancer resection can be im- proved by oral intake of calcium carbonate,which is safe and effective.