血清和尿RBP、β2-MG与新生儿高胆红素血症严重程度的相关性分析

Correlation Analysis of Serum and Urine RBP,Beta-2-MG and Neonatal Byperbilirubinemia Severity

目的评价血清和尿视黄醇结合蛋白(RBP)、β2微球蛋白(β2-MG)在新生儿高胆红素血症中的价值,为高胆红素血症的管理提供指标依据。方法 2014年12月～2016年12月,医院收治141例高胆红素血症新生儿,依据新生儿高胆红素血症的分级标准:47例纳入重度组,47例纳入极重度组,47纳入危险组,选择同期47例健康新生儿纳入对照组。于入选后,治疗前、1周后,检测血清和尿RBP、β2-MG与血清总胆红素水平。结果四组患儿治疗前后血清和尿RBP、β2-MG多组间比较差异有统计学意义(P <0.05),对照组、重度组、极重度组、危险组指标水平呈递增关系;治疗前后,血清总胆红素水平与血清和尿RBP、β2-MG存在正相性,其中治疗前尿RBP、β2-MG与血清总胆红素水平存在强相关(r>0.6)。结论血清和尿RBP、β2-MG水平与新生高胆红素血症严重程度存在相关性,尿RBP、β2-MG可辅助判断疾病严重程度。

Objective To evaluate the value of serum and urinary retinol binding protein （RBP） and beta 2microglobulin（2-MG） in neonatal hyperbilirubinemia. Methods From December 2014 to December 2016,the hospitaltreated 1 4 1 cases of neonatal hyperbilirubinemia,grading criteria of neonatal hyperbilirubinemia,4 7 cases with severehyperbilirubinemia were included in the severe group,47 cases with extremely severe hyperbilirubinemia were inclued inthe extremely severe group,and the risk hyperbilirubinemia group was included in the dangerous group,at the same period47 cases of healthy neonates were selected as control group. Before and after treatment,serum and urine RBP,beta 2-MGand serum total bilirubin levels were measured before and 1 weeks after treatment. Results Four groups of patients beforeand after treatment,serum and urine RBP and beta 2-MG were statistically significant difference（P 〈0.05）,the controlgroup,severe group,extremely severe group,and the risk group showed an increasing relationship; Before treatment andafter treatment,serum total bilirubin levels were positively correlated with serum and urine RBP and beta 2-MG,amongwhich urine RBP,beta 2-MG and serum total bilirubin levels were strongly correlated（r 〉0.6）. Conclusion The levels of serum and urine RBP,beta 2-MG levels were correlated with the severity of neonatal hyperbilirubinemia,and urinaryRBP and beta 2-MG could assist in judging the severity of Hyperbilirubinemia.