初治儿童和青少年肾母细胞瘤COG-RTC临床研究结果汇总

A summary of the COG-RTC clinical research results in the initial treatment for Wilms tumor in children and adolescents

儿童肾脏肿瘤约占儿童癌症7%。绝大多数是肾母细胞瘤,但15~19岁青少年肾癌较为常见。医疗发达国家临床研究中,儿童肾母细胞瘤的总体存活率已达90%。美国儿童肿瘤协作组肾脏肿瘤委员会(COG-RTC)是国际上公认的在儿童肾脏肿瘤临床研究权威学术组织之一,其治疗方案的基本路线是先手术(如果可行),然后化疗,部分患儿接受放疗。该文针对COG-RTC近年发表的临床研究结果进行汇总,以期为临床医生治疗儿童肾母细胞瘤病人时提供参考。

Childhood kidney tumors account for about 7% of all childhood cancers. Most childhood kidney tumors are Wilms tumor,but in the 15-to 19-year age group,most tumors are renal cell carcinoma. In medically developed countries,clinical trials in Wilms tumor（WT）have resulted in overall survival rates of greater than 90%. Children＇s Oncology Group Renal Tumor Committee（COG-RTC）is one of the clinical study groups internationally known for its clinical research in childhood kidney tumor. Its standard treatment for children with Wilms tumor consists of initial nephrectomy（when feasible） followed by chemotherapy and,in some patients,radiation therapy. This summary reviewed peer-reviewed,evidence-based reports about the treatment for Wilms tumor published recently and intended to be a resource to assist clinicians who care for children with Wilms tumor.