儿童复杂性热性惊厥285例多因素临床分析

Complex febrile seizure in children:A multivariate clinical analysis of 285 cases

目的探讨儿童复杂性热性惊厥(CFS)的临床特征,提高儿科医生对CFS的认识。方法采用回顾性分析的方法对2012年1月至2016年12月中国医科大学附属盛京医院收治的285例CFS患儿临床资料进行分析。结果 CFS发作影响因素较多,病原体感染以肺炎支原体和(或)衣原体近期感染(38.9%,111/285)多见,血清离子氯含量异常降低在CFS 3种表现形式中差异有统计学意义[(104.9±3.6)mmol/L、(103.3±3.0)mmol/L、(104.4±2.7)mmol/L,P<0.05],影像学及脑电图检查在惊厥再次发作及继发癫痫中有异常表现(CT 29%,MRI39%,EEG 17%,VEEG 26%,AEEG 53%)。结论 CFS发作影响因素较多,影像学及EEG检查对评估惊厥再次发作及继发癫痫有指导意义。

Objective To explore the clinical features of complex febrile seizure（CFS）in children,and to improve the understanding on CFS in pediatricians. Methods Retrospective analysis of clinical data of 285 children with CFS was performed. Results There were many factors affecting CFS,and the infection of different pathogens and abnormal serum ion content may cause CFS. CT/MRI and electroencephalogram（EEG）were useful for assessing the onset of convulsion and secondary epilepsy. Conclusion There were many factors affecting CFS,the imaging examination and EEG were valuable in evaluating the recurrent convulsion and secondary epilepsy.