降钙素原、血清前白蛋白、C反应蛋白联合检测对胰腺炎病情评估的作用

The analysis of procalcitonin,prealbumin and C reactive protein for evaluation of disease status of acute pancreatitis

为了解降钙素原、血清前白蛋白、C反应蛋白联合检测用于急性胰腺炎病情评估的效果,并拟合分析模型,用于急性胰腺炎病情评估的预判,研究者于2015年6月至2017年9月期间,对在本院就诊的93例急性胰腺炎患者、58例慢性胰腺炎患者、206例健康者进行调查。比较3组对象降钙素原(procalcitonin, PCT)、血清前白蛋白(prealbumin, PA)、C反应蛋白(C-reactive protein, CRP)含量的差异;分析不同临床Balthazar CT分级的急性胰腺炎患者PCT、PA、CRP含量差异,并探讨Balthazar CT分级与3个指标含量的相关性;通过多因素回顾分析的方法分析自变量(PCT、PA、CRP)对因变量(Balthazar CT分级)的综合影响。研究发现,3组患者PCT、PA、CRP含量的差异均有统计学意义(P<0.05);急性胰腺炎患者中,不同Balthazar CT患者3项指标含量差异显著(P<0.05);Balthazar CT分级与PCT(Pearson=0.83,P<0.05)、PA(Pearson=0.67,P<0.05)、CRP(Pearson=0.53,P<0.05)含量密切相关;以Balthazar CT分级为因变量,以PCT、PA、CRP含量为自变量,通过逐步回归的方法拟合多因素Logistic回归方程有统计学意义,3个因素对结果影响大小(OR)依次为:PCT(6.29)、PA(2.25)、CRP(2.05)。综上, PCT、PA、CRP单指标检出情况对胰腺炎的发生和病情(急性/慢性)影响明显;3个指标与急性胰腺炎患者Balthazar CT分级密切相关;3个指标与Balthazar CT分级拟合的模型可用于患者病情的预判。

We aimed to evaluate the combined detection of procalcitonin（PCT）,prealbumin（PA）and C reactive protein（CPR）for acute pancreatitis and to establish an analytical model.93 patients with acute pancreatitis,58 patients with chronic pancreatitis and 206 normal controls were investigated.The differences of PCT,PA and CRP in patients with different Balthazar CT grading were analyzed,and the correlation among the three indexes and Balthazar CT classification was analyzed,and the comprehensive effects of the three indexes on the classification of Balthazar CT were analyzed.In patients with acute pancreatitis,there were significant differences among the three indexes of Balthazar CT patients（P〈0.05）.Balthazar CT classification was closely related to PCT（Pearson=0.83,P〈0.05）,PA（Pearson=0.67,P〈0.05）and CRP（Pearson=0.53,P〈0.05）.Balthazar CT grading as dependent variable,PCT,PA,CRP content as the independent variable,we established equation of the three factors that affect the disease（OR）in the order：PCT reduction（6.29）,PA（2.25）,CRP（2.05）.In conclusion,PCT,PA and CRP have significant effects on the evaluation of pancreatitis.The three indexes were closely related to patients＇ Balthazar CT grading.The established equations can be used to predict patient＇s prognosis.