自噬与神经系统疾病

Autophagy and neuronal diseases

自噬是通过对衰老蛋白、受损细胞器消化降解再利用来维持细胞正常稳态的一个动态的过程。近年来随着学者对自噬研究的深入，发现自噬参与许多神经系统疾病的病理改变过程，并在其中发挥重要作用。本文就自噬在常见神经系统疾病的发病及其调控机制方面的相关研究进展进行综述，从而加深对自噬的了解，引起研究者对动态调控自噬及减轻自噬流损伤的关注。

Autophagy is a dynamic process that allows recycling of long-lived proteins and damaged organelles into biosynthetic materials for maintaining the normal cellular homeostasis. Recently, accumulating evidence has indicated that autophagy played important roles in the pathogenesis of neuronal diseases. In this article, the research progress of autophagy in the pathogenesis and regulation mechanism of common nervous system diseases were reviewed to deepen the understanding of autophagy, and arouse researchers＇ attention on dynamic regulation of autophagy and alleviating autophagic flow injury.