巨噬细胞铁代谢Hepcidin-Fpn1轴及其在动脉粥样硬化的作用

Hepcidin-Fpn1 axis of macrophage iron metabolism and its role in atherosclerosis

动脉粥样硬化（As）与铁代谢相关联,但斑块中聚集的铁是产生致病作用还是只是在As疾病发生发展过程中溶血等导致的一个单纯后果还存在争议。巨噬细胞在As斑块的形成和发展中发挥关键作用。本文总结巨噬细胞铁代谢与As的研究进展。首先介绍在巨噬细胞铁代谢中发挥重要作用的Hepcidin-Fpn1轴;接着从炎症、感染、斑块内出血3个方面介绍巨噬细胞铁代谢对As发生发展的影响;最后介绍与铁代谢相关的As治疗的新思路。

Atherosclerosis（As） is associated with iron metabolism. It is still controversial whether the iron gathered in plaque is a pathogenic factor or a simple consequence caused by hemolysis in the development of As disease. Macrophages play a key role in the formation and development of As plaques. This review summarizes the research progress of macrophage iron metabolism and As. This paper first introduces the Hepcidin-Fpn1 axis that plays an important role in macrophage iron metabolism,and then introduces the effect of macrophage iron metabolism on the development of As from 3 aspects of inflammation,infection and hemorrhage in plaque. Finally,the new ideas of As therapy related to iron metabolism are introduced.