微小RNA对缺血再灌注损伤心肌线粒体作用的研究进展

Research progress in the study of myocardial mitochondrial effect on ischemia reperfusion injury by microRNA

心肌缺血再灌注损伤是造成心肌结构损伤、功能障碍的一种病理生理过程,进一步发展会导致级联的多器官功能障碍。线粒体是一种结构功能复杂且对外界环境反应敏感的细胞器,其稳态的维持依赖于正常形态、功能及数量的相对稳定状态。线粒体质量与代谢异常和心血管疾病尤其是心肌缺血再灌注损伤的发生密切相关。微小RNA是近年来研究较多的在缺血再灌注损伤心肌线粒体保护中具有重要作用的调控因子。本文通过微小RNA对心肌缺血再灌注损伤时线粒体形态、功能、线粒体自噬和线粒体DNA几个方面的调控机制与相关前沿进展进行综述,为微小RNA参与缺血再灌注心肌线粒体损伤的后续研究提供一定的理论依据。

Myocardial ischemia reperfusion injury is a pathophysiological process that causes damage to myocardial structure and dysfunction,and further development leads to multi-organ dysfunction of cascade. Mitochondria is an organelle that is complex in structure and responsive to external environment,and its steady state depends on the relative stability of normal form,function and quantity. Mitochondrial quality and metabolic abnormalities are closely related to the occurrence of cardiovascular diseases,especially myocardial ischemia reperfusion injury. MicroRNAs are the regulatory factors that have important role in myocardial mitochondrial protection during ischemia reperfusion injury in recent years. In this paper,the regulation mechanism of mitochondrial morphology,function,mitochondrial autophagy and mitochondrial DNA by microRNAs were reviewed. It provides a theoretical basis for the follow-up study of microRNA in ischemia reperfusion myocardial mitochondrial injury.