参芝消平胶囊质量标准的提高

Quality Standard Improvement for Shenzhi Xiaoping Capsules

目的:建立参芝消平胶囊的质量标准。方法:采用显微镜对黄芪进行显微特征鉴别;采用TLC法对参芝消平胶囊中黄芪、枳壳、甘草进行定性鉴别;采用HPLC法测定人参中人参皂苷Rb_1的含量。结果:显微特征明显; TLC鉴别黄芪、枳壳、甘草特征斑点清晰,分离度良好;含量测定人参皂苷Rb_1在47. 06～376. 5μg·ml^(-1)范围内线性关系良好(r=0. 999 9),平均回收率为102. 7%,RSD为1. 1%(n=6)。结论:本方法简便易行,专属性强,可用于参芝消平胶囊的质量控制。

Objective： To establish the quality standard for Shenzhi Xiaoping capsules. Methods： The characteristics of Astragali Radix were identified by microscopy. TLC was adopted to identify Astragali Radix,Fructus Aurantii and Glycyrrhiza uralensis. The content of ginsenoside Rb_1 in Panax ginseng was determined by HPLC. Results： The microscopic characteristics were obvious. The TLC spots were clear with highly specific identification and good separation. The linear range of ginsenoside Rb_1 was 47. 06-376. 5 μg·ml^-1（ r = 0. 999 9）,and the average recovery was 102. 7% with the RSD of 1. 1%（ n = 6）. Conclusion： The method is simple and specific,which can be used for the quality control of Shenzhi Xiaoping capsules.