肺部真菌微生物组研究进展

The study on lung mycobiome:a review

人体微生物组在健康维护与疾病发展过程中发挥着重要作用。最新研究发现,曾经被视为无菌部位的肺部,其微生物构成也非常丰富,不过针对肺微生物组方面的研究仍然处于早期阶段。真菌及相关基因产物作为人体微生物组的重要组成部分,其在肺部或其他疾病发生与防治方面所具有的潜在功能和意义尚不清晰。本文主要对肺部真菌微生物组的研究技术方法、群落结构特征与功能作用等进行综述,分析了该研究领域目前存在的主要不足,并提出了相关研究建议。

The human microbiome plays an important role in health maintenance and disease development. Although this field of study is still in its early stage, the traditionally considered sterile lungs can harbor a diverse microbial community. As an important part of human microbiome, the role of fungi and their gene products in the development, prevention and treatment of lung diseases is still unclear. This review describes the current research techniques, community structure, and function of the lung mycobiome, and analyzes the major problems in this field and gives some advice for future study.