硫辛酸分子印迹膜及其抗氧化效果

Studies on α-lipoic acid molecularly imprinted membrane and its antioxidant properties

以α-硫辛酸(ALA)为模板分子,N-乙烯基己内酰胺(NVCL)为温敏性功能单体,在制备硫辛酸分子印迹聚合物(ALA-MIPs)的基础上,结合膜技术,选用聚丙烯腈(PAN)和聚偏氟乙烯(PVDF)作为成膜材料,以异相粒子填充膜法制备了ALA-MIPs共混膜,通过扫描电镜考察了分子印迹膜(MIM)的微观形貌,研究了机械性能、亲水性、吸水性、ALA的释放特性。结果表明,PVDF膜具有更好的机械性能和疏水性能,PAN膜有较好的ALA释放量,两者都在20℃下存在温敏性释放。通过测定分子印迹膜在植物油中的POV值,发现PAN-MIM膜有更好的抗氧化效果。

Thermo-sensitive α-lipoic acid molecularly imprinted polymers（ALA-MIPs） were synthesized through pre-polymerization using α-lipoic acid as a functional monomer and N-vinylcaprolactam（NVCL） as both thermo-sensitive monomer and functional monomer. Poly（acrylonitrile）（PAN） and Poly（vinylidene fluoride）（PVDF） were used as the main raw material to synthesis molecularly imprinted membranes through the heterogeneous particle-filling method by adding ALA-MIPs. The morphology of the molecularly imprinted membrane（MIM） was investigated by scanning electron microscopy. The mechanical properties, hydrophilic properties,water absorption abilities,and ALA release properties of the membrane were also investigated. The results show that the PVDF membrane has better mechanical properties and hydrophobic properties when adding PVDF for 12 g/100 g,whereas the PAN membrane has better release abilities of ALA at 20 ℃. By measuring the POV value of rapeseed oils,the PAN-MIM was found to has better antioxidant effects.