低能量激光治疗骨关节炎的循证依据

Evidence-based proofs for low-level laser therapy of osteoarthritis

低能量激光治疗作为一种通过生物化学改变而治疗疾病的有效手段被广泛用于临床,该文整理收集了近年来关于低能量激光治疗骨关节炎的基础研究和临床试验的文献,对不同波长的低能量激光治疗骨关节炎的机制及疗效的循证依据进行概述。结果发现低能量激光治疗通过增加细胞增殖、刺激成纤维细胞产生胶原蛋白、进行骨修复和调节炎症标志物等从而产生缓解疼痛、调节炎症反应、保护软骨以及预防软骨退化的作用,且不同波长具有不同的疗效,对于在临床中的应用至关重要。

Low-level laser therapy （LLLT） as an effective therapy with biochemical change has gained more and more attention in clinical treatment. This review sorts many fundamental experiment studis and clinical applications about LLLT published in recent years, and summarizes the advances of evidence-based proofs of the potential mechanisms of LLLT with different wavelengths in treating osteoarthritis. It shows that LLLT could relieve pain, modulate inflammatory response, protect cartilage, and prevent cartilage degeneration, through increasing cell proliferation, stimulating fibroblasts to produce collagen, bone repair, and regulating inflammatory markers and so on. LLLT with different wavelengths has different effect, and it is important for clinical practice.