中性粒细胞淋巴细胞比值和血小板淋巴细胞比值与突发性聋相关性的研究

Study on the relationship between neutrophil lymphocyte ratio and platelet lymphocyte ratio and sudden deafness

目的:探讨中性粒细胞淋巴细胞比值(NLR)和血小板淋巴细胞比值(PLR)与突发性聋发病的关系及其对预后的影响。方法:203例突发性聋(突聋组)患者治疗前均行纯音测听、血常规等相关检查,按照突聋的诊断标准分型并计算NLR和PLR,规律、全程治疗后再次复查纯音测听并记录听力变化情况。以203例健康者作为对照组。结果:突聋组NLR和PLR中位数分别为2.8和126.4,对照组分别为1.4和96.9,2组差异有统计学意义(P<0.01);恢复组NLR和PLR中位数分别为2.4和116.9,未恢复组分别为3.4,145.0,2组差异有统计学意义(P<0.05);而NLR和PLR在低中频下降型、高频下降型、平坦型、全聋型进行两两比较,差异无统计学意义(P>0.05)。结论:突聋患者的NLR和PLR均有升高,未恢复组较恢复组高,支持炎症理论在突聋发病机制中的作用,因此NLR和PLR可作为临床医师评估突聋预后的新型可靠指标,而NLR和PLR与听力分型可能无明显相关性。

Objective：To investigate the relationship between neutrophil lymphocyte ratio（NLR）and platelet lymphocyte ratio（PLR）and the incidence of sudden deafness and its impact on the prognosis.Method：The clinical data of 203 patients with sudden deafness was retrospectively analyzed.Pure tone audiometry,complete blood count and other related examinations were performed before treatment.Hearing type was depending on the diagnostic criteria of sudden deafness;NLR and PLR were calculated.After that,pure tone audiometry was reviewed again and the hearing changes were recorded.The control group was 203 healthy persons without infectious disease.Result：The median NLR and PLR of the sudden deafness group were 2.8 and 126.4,respectively,and that of the control group were 1.4 and 96.9 respectively.The difference between the two groups was statistically significant（P0.01）.The median NLR and PLR of the recovery group were 2.4 and 116.9,and that of the unrecovered group were 3.4 and 145.0,respectively,the difference between the two groups was statistically significant（P0.05）.No significant difference of NLR or PLR was observed among the low medium frequency type,high frequency type,flat type and total deafness type for each two pairs（P0.05）.Conclusion：NLR and PLR are higher in patients with sudden deafness than the healthy controls,and are higher in the unrecovered group than in the recovery group.Our result supports the role of inflammatory theory in the pathogenesis of sudden deafness.Therefore,NLR and PLR can be used as a new reliable indicator to evaluate the prognosis of sudden deafness,but NLR and PLR may not have a significant correlation with hearing classification.