青蒿素及其衍生物抗头颈癌作用研究进展

Progress in the study of artemisinin and its derivatives against head and neck cancer

头颈部恶性肿瘤是世界上最常见的恶性肿瘤之一，全球每年有超过600000例的新发病例。在治疗头颈部恶性肿瘤时，常采用手术切除、放射治疗以及化学药物治疗等多手段联合运用的方法，但治疗结果常不尽人意，且预后较差。

The head and neck cancer is one of the most common malignant tumors in the world.There are more than 600 000 new cases in the world every year.Cisplatin is often used in the treatment of head and neck cancer at present.However,because of its side effects and drug resistance,cisplatin often failed in the treatment of head and neck cancer.Artemisinin and its derivatives as first-line antimalarial drugs have the advantages of high efficiency,low toxicity and so on.Further study found that artemisinin and its derivatives had cytotoxic effects against head and neck cancer through inducing cell cycle arrest,inducing tumor cell apoptosis and inhibiting cell invasion and migration,oxidative damage,blocking the cell signal transduction and inhibiting angiogenesis.Studying the anti-tumor effects of artemisinin and its derivatives allows for development of safer and more effective antitumor drugs and pain-reduction caused by diseases and traditional treatment,then improve the survival rate and life quality of patients with head and neck cancer.This article reviews the progress in the study of artemisinin and its derivatives in the treatment of head and neck cancer.