哈尔滨市接受抗病毒治疗艾滋病病毒感染者/患者睡眠障碍和焦虑及抑郁发生情况

Sleep disorder,anxiety and depression among patients with antiviral therapy for HIV/AIDS in Harbin city of China

目的调查研究哈尔滨市接受抗病毒治疗的人类免疫缺陷病毒(human immunodeficency virus,HIV)感染者/艾滋病(acquired immunodeficiency syndrome,AIDS)患者睡眠障碍、焦虑及抑郁(sleep disorder,anxiety,depression,SAD)的发生率、影响因素和相关性。方法采用横断面调查方法,于2017年1月至2017年4月,随机抽取哈尔滨医科大学附属第四医院收治的接受抗病毒治疗的艾滋病患者共309例,通过医院用焦虑抑郁评估量表(anxiety and depression assessment scale,HAD)、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)对其进行问卷调查。使用SAS 9.1.3进行资料统计分析。结果完成PSQI问卷的患者中,54.05%(167/309)的患者出现睡眠障碍(PSQI评分>5),其中10.03%(31/309)的患者睡眠质量较差(PSQI评分为11~15),0.65%(2/309)的患者睡眠质量为很差(PSQI评分为16~21);完成HAD问卷的患者中,焦虑发生率为39.48%(122/309),抑郁发生率为32.36%(100/309)。服用兴奋剂、睡眠情况、情绪低落和用药情况对睡眠质量的构成差异有统计学意义(P<0.05),服药情况、睡眠情况、情绪低落对是否焦虑的构成差异有统计学意义(P<0.05),年龄、婚姻状况、教育水平、职业、朋友知情情况、情绪低落对是否抑郁的构成差异有统计学意义(P<0.05)。睡眠障碍、抑郁、焦虑的主效应以及睡眠障碍与抑郁、睡眠障碍与焦虑、抑郁与焦虑的二阶交互作用均有统计学意义。结论哈尔滨市抗病毒治疗HIV感染者/AIDS患者的睡眠障碍、焦虑、抑郁存在相关性,睡眠障碍的患者通常伴有焦虑、抑郁的症状,抑郁的患者通常也伴有焦虑。

Objective To investigate the incidence,influencing factors and correlation of sleep disorder,anxiety and depression（S.A.D.）among HIV carriers and AIDS patients with antiviral therapy in Harbin city of China. Methods A cross-sectional survey was conducted from January to April 2017 and 309 patients with antiviral therapy were selected by convenience sampling from The Fourth Affiliated Hospital of Harbin Medical University.Quality of life scale and Social Support Rating Scale（SSRS）were used.Data were analyzed by SAS9.1.3. Results Based on the Pittsburgh sleep quality index（PSQI）,54.05%（167/309）patients demonstrated sleep disorders（PSQI score〉5）and of which,10.03% patients with poor sleep quality（PSQI score 11-15）,0.65%patients with PSQI score at 16-21.Hospital anxiety and depression scale（HADS）survey found that 39.48%（122/309）anxiety rate,the depression rate was 32.36%（100/309）.Sleep quality is significantly related to the status of doping,sleep,depression and medication（P〈0.05）.Age,marital status,education level,occupation,friends informed are correlated to depression（P〈0.05）. Conclusions Among patients with antiviral therapy for HIV/AIDS in Harbin of China,sleep disorder is significantly associated with anxiety and depression.Patients with sleep disorders are often associated with anxiety and depression symptoms,and depressed patients are often accompanied by anxiety.