摘要
针对肿瘤组织的微环境,结合树状大分子的特点可以构建定向可控药物、基因传递系统,实现化学或基因治疗中的高效低毒.本综述从树状大分子的结构出发,总结了其纳米载体在肿瘤治疗中的最新进展,尤其重点讨论了传统树状大分子、树状大分子偶联物、可自组装的两亲性树状大分子、杂化树状大分子及自身具有药理活性的树状大分子作为药物或基因递送载体的应用.我们希望本综述将有助于启发未来的相关研究,以进一步拓展这种材料在肿瘤治疗中的新应用.
This review discusses recent studies on dendrimer-based nanoparticles in cancer chemotherapy and gene therapy. In order to achieve the high efficacy and low side effects of chemotherapy and gene therapy, it is essential to combine the unique features of dendrimers and the specific tumor microenvironment to target delivery and control release of therapeutic agents to tumor tissues and cells. Strategies to design the dendrimer-based delivery system in this review include non-modified dendrimers, dendrimer conjugates, assembled amphiphilic dendrimers, nanohybrid dendrimer carriers and dendrimers with inherent activity. In addition, specific functional groups on these dendrimers as stimuli-responsive system for targeting delivery and controlled release of therapeutic agents are discussed.
作者
姜雷
周森森
张小可
武伟
蒋锡群
Lei Jiang;Sensen Zhou;Xiaoke Zhang;Wei Wu;Xiqun Jiang(MOE Key Laboratory of High Performance Polymer Materials and Technology,and Department of Polymer Science ＆ Engineering,College of Chemistry ＆ Chemical Engineering,Nanjing University,Nanjing 210093,China;State Key Laboratory of Natural Medicines,Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China)
基金
supported by the National Natural Science Foundation of China (81601594, 51690153, 21474045 and 21720102005)
