超分子枝状聚合物用于疾病诊断与治疗（英文）

Supramolecular dendritic polymers for diagnostic and theranostic applications

超分子枝状聚合物(SDP)为疾病的诊断与治疗提供了新的方法.这种聚合物具有非共价链接的大分子与枝状结构以及三维管状结构.这种结构形成了动态可逆的理化特性(如高溶解性,粘度低以及富含大量的功能团端基).可逆的非共价相互作用使得SDP易于制备,具有智能响应以及良好的代谢性.这些特性决定了SDP在疾病诊断与治疗中起到关键性作用.本综述简要总结了具有特定结构、性质和功能的SPD分子的合成与设计. SPD在诊断治疗中的应用促进了化学、材料科学以及生物医学的交叉研究.

Supramolecular dendritic polymers（SDPs）provide a new opportunity for the precision diagnosis and treatment of diseases. SDPs are a novel class of non-covalently bonded macromolecules with highly branched structure and three-dimensional globular topology, which exhibit dynamic/reversible features and unique physical/chemical properties（e.g., high solubility, low viscosity, and numerous functional terminal groups）. The reversibility of non-covalent interactions endows SDPs with the ability of facile preparation, smart responsiveness, and simple metabolism. These special characteristics determine the properties of SDPs, which are the key points for theranostic applications, including diagnosis,therapy, and theranostics. In this review, we briefly summarize the design and synthesis of SDPs with aimed structures,properties, functions as well as their present diagnostic and theranostic applications. These developments on the preparation and applications of SDPs for diagnostic and theranostic purpose promote interdisciplinary research fields of chemistry, material and biomedical science.