先天性膈疝肺表面活性物质的变化

Research advances of pulmonary surfactant in congenital diaphragmatic hernia

先天性膈疝（congenital diaphragmatic hernia,CDH）是威胁患儿生命的临床重要难题,重症患儿产后死亡率仍然很高,肺顺应性降低是导致患儿产后死亡的重要原因.除肺发育不良外,肺表面活性物质（pulmonary surfactant,PS）的缺乏也可能是导致CDH时肺顺应性降低的原因.PS可以降低肺泡的表面张力,在维持正常肺功能方面具有重要作用.CDH患儿是否存在PS的缺乏,目前针对这一问题,国内外众多研究结果尚未一致定论.

Congenital diaphragmatic hernia （CDH）is a significant clinical problem and carries a high mortality in severe cases.Low lung compliance is a major cause for its high mortality.Besides pulmonary hypoplasia,pathophysiology of low lung compliance in CDH may also include pulmonary surfactant （PS）deficiency.PS maintains low alveolar surface tension and is therefore essential for normal lung function.Is CDH accompanied with pulmonary surfactant deficiency？ Despite many researches on this subject,the results have remained non-convincing.