孕妇IgG抗A(抗B)的效价积分对新生儿溶血病贫血严重程度的预判价值

The predictive value of IgG anti-A/B titer score on severity of hemolytic disease of newborn

目的 :探讨采用母亲体内Ig G抗A(抗B)的效价积分对新生儿溶血病严重程度进行预判的价值。方法 :检测27例新生儿溶血病患儿的红细胞计数、血红蛋白、红细胞比容和其母亲的Ig G抗A(抗B)效价、效价积分,对其进行趋势线计算和相关性分析。结果:母亲的Ig G抗A(抗B)效价积分和效价上升时,患儿的红细胞计数、血红蛋白含量、红细胞比容都下降;而在母亲抗体效价相同的情况下,效价积分越高,患儿的红细胞计数、血红蛋白含量、红细胞比容越低。相关性分析显示,在对新生儿溶血病患儿的贫血程度的预判中,效价积分与患儿血红蛋白含量间的相关系数为-0.966,其母亲的Ig G抗A(抗B)效价积分与患儿贫血程度间的相关性比抗体效价更密切。结论:孕妇Ig G抗A(抗B)的效价积分在预判患儿贫血的严重程度中具有一定临床价值。

Objective： To study the correlation of Ig G anti-A/B titer score and the severity of hemolytic disease of newborn. Methods： The red blood cell count, hemoglobin and hematocrit value of 27 newborn with hemolytic disease and the Ig G anti-A/B titer and titer score of their mother were measured and their correlations were analyzed. Results： With the increase in Ig G anti-A/B titer and titer score of mother, the red blood cell count, hemoglobin and hematocrit values of newborn with hemolytic disease decreased. At the same Ig G anti-A/B titer, the higher the titer score, the lower the red blood count, hemoglobin and hematocrit value were. Conclusions： According to the correlation analysis, the titer score is more closely related to the severity of hemolytic disease of newborn. For hemoglobin, the correlation coefficient was-0.966.The Ig G anti-A/B titer score was of more clinical significance in predicting the severity of hemolytic disease in newborn.