EV71感染与固有免疫应答相互作用关系的研究进展

Research progress in the interaction between enterovirus 71 infection and host antiviral innate immunity

肠道病毒71型(enterovirus 71,EV71)是引起手足口病的主要病原体之一,可引起严重并发症,致残率及病死率较高,是严重危害婴幼儿健康的重大公共卫生问题之一。EV71感染后,宿主启动固有免疫应答抵御感染,而病毒则通过一系列机制逃逸固有免疫的抑制和清除,二者之间存在着博弈关系,两者斗争的结果与EV71感染所致手足口病的病程和结局密切相关。本文就近年来EV71感染与固有免疫应答之间相互作用关系的研究进行综述,旨在为后续研究的深入开展和新型疫苗、药物的研发提供线索和思路。

Enterovirus 71 （EV71） is one of the main pathogens causing hand foot and mouth disease （ HFMD）, which is associated with severe complications, leading to high morbidity and mortality. It is a major public health problem that is harmful to the health of infants and young children. During EV71 infection, the host antiviral innate immune response was activated to clear and against EV71, while EV71 can escape the elimination of innate immunity through a series of mechanisms. There is a combat relationship between EV71 and innate immunity, and the results are closely related to the course and outcome of EVT1 infection in HFMD patients. This review focuses on the research progress of the interaction between EV71 infection and innate immune response in recent years and try to provide clues and reference for further EVT1 research, vaccine and drug development.