氯沙坦对社区原发性高血压患者微量蛋白尿的影响作用研究

Effect of Losartan on Microalbuminuria in Community Patients with Essential Hypertension

目的分析氯沙坦对社区原发性高血压患者微量蛋白尿的影响。方法选取100例医院收治的社区原发性高血压患者作为观察对象,根据治疗方案的不同分为分为观察组与对照组,每组50例。对照组采用氢氯噻嗪治疗,观察组则采用氯沙坦治疗。观察两组患者的临床疗效,比较两组患者治疗前后的血压值以及尿微量白蛋白的变化,同时记录两组患者治疗期间发生的不良反应。结果观察组的临床疗效明显高于对照组(P<0.05);观察组治疗后血压以及尿微量白蛋白水平明显高于对照组(P<0.05);观察组不良反应发生率明显低于对照组(P<0.05)。结论氯沙坦在社区原发性高血压具有较好的临床疗效,能够有效降低患者的血压以及尿微量白蛋白水平,并且具有较高的安全性,值得在临床中推广使用。

Objective to analyze the effects of losartan on microalbuminuria in community patients with essential hypertension. Methods 100 cases of community primary hypertension patients admitted by the hospital were selected as the observation subjects. According to the different treatment plans, they were divided into observation group and control group, with 50 cases in each group. The control group was treated with hydrochlorothiazide and the observation group was treated with clozapine. Adverse reactions during treatment were also recorded in both groups. Results the clinical efficacy of the observation group was significantly higher than that of the control group（P〈0.05）.Blood pressure and urinary microalbumin levels in the observation group were significantly higher than those in the control group after treatment（P〈0.05）.The incidence of adverse reactions in the observation group was significantly lower than that in the control group（P〈0.05）. Conclusion losartan has good clinical efficacy in community primary hypertension. It can effectively reduce patients＇ blood pressure and urinary microalbumin level, and has high safety, which is worthy of clinical application.