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FKBPs与神经退行性疾病 被引量：2

FK506-BINDING PROTEINS AND NEURODEGENERATIVE DISEASES
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作者 赵丽琴 肖军海 黄蔚 李松
机构地区 军事医学科学院毒物药物研究所
出处 《药学学报》 CAS CSCD 北大核心 2002年第9期743-748,共6页 Acta Pharmaceutica Sinica
基金 国家重点基础研究规划项目 (G19980 5110 7) 国家自然科学基金海外青年学者合作研究基金 ( 3992 80 11) 国家自然科学基金项目 ( 30 0 0 0 2 15)
关键词 亲免素受体 FKBPs 神经退行性疾病 小分子神经营养药物 免疫抑制 神经再生 FKBPs配体 immunophilins FK506 binding proteins (FKBPs) neurodegenerative diseases
分类号 R742.5 [医药卫生—神经病学与精神病学] R749.1 [医药卫生—神经病学与精神病学]
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参考文献33

  • 1Sharkey J, Butcher SP. Immunophilins mediate the neuroprotective effects of FK506 in focal celebral ischaemia [J]. Nature, 1994,371(6495):336-339.
  • 2Takahashi N, Hayano T, Suzuki M. Peptidyl-propyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin [J]. Nature, 1989,337(6206):473-475.
  • 3Harding MW, Galat A, Uehling DE, et al. A receptor for the immuno-suppressant FK506 is a cis-trans peptidyl-prolyl isomerase [J]. Nature, 1989,341(6244):761-763.
  • 4Rahfeld JU, Rucknagel KP, Schelbert B, et al. Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases. Amino acid sequence and recombinant production of parvulin [J]. FEBS Lett, 1994,352(2):180-184.
  • 5Van Duyne GD, Standaert RF, Karplus PA, et al. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin [J]. J Mol Biol, 1993,229(1):105-124.
  • 6Pfluegl G, Kallen J, Schirmer T, et al. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex [J]. Nature, 1993,361(6407):91-94.
  • 7Friedman J, Weissman I. Two cytoplastic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA [J]. Cell, 1991,66(4):799-806.
  • 8Liu J. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes [J]. Cell, 1991,66(4):807-815.
  • 9Freman DA, Klee CB, Bierer BE, et al. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A [J]. Proc Natl Acad Sci USA, 1992,89(9):3686-3690.
  • 10Bierer BE, Mattila PS, Standaert RF, et al. Two distinct signal transmission pathways are inhibited in T-lymphocytes by complexes formed between an immunophilin and either FK506 or rapamycin [J]. Proc Natl Acad Sci USA, 1990,87(23):9231-9235.

同被引文献38

  • 1吕德成,袁先厚,张卫国,傅重洋.利用神经再生室观察FK506促进神经再生的实验研究[J].中华医学杂志,2005,85(28):1978-1981. 被引量：9
  • 2Fischer G, Bang H. Mech C. Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides [J]. Biomed Biochim Acta. 1984.43(10) :1101-11.
  • 3Takahashi N. Hayano T. Suzuki M. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin [J].Nature. 1989,Feb 2;337(6206) :473-5.
  • 4Harrison RK, Stein RL. Substrate specificities of the peptidyl prolyl cis-trans isomerase activeities of cyclophilin and FK-506 binding protein:evidence for the existence of a family of distinct enzymes[J]. Biochemistry. 1990,Apr 24;29(16): 3813-6.
  • 5Galat A. Lane WS, Standaert RF et al. A rapamycin-selective 25-kDa immunophilin [J]. Biochemistry. 1992, Mar 3 ; 31 (8):2427-34.
  • 6Tropschug M, Wachter E, Mayer S et al. Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding[J]. Nature. 1990,Aug 16;346(6285) :674-7.
  • 7Harding MW, Galat A, Uehling DE,Schreiber SL. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase[J]. Nature. 1989.Oct 26;341(6244):758-60.
  • 8Pahl A, Keller U. FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type [J]. J Bacteriol. 1992,Sep;174(18):5888-94.
  • 9Riviere S, Menez A, Galat A. On the localization of FKBP25 in T-lymphocytes[J]. FEBS Lett. 1993, Jan 11 ;315(3) :247-51.
  • 10Jin YJ, Burakoff SJ. The 25-kDa FKS06-binding protein is localized in the nucleus and associates with casein kinase Ⅱ and nucleolin[J]. Proc Natl Acad Sci U S A. 1993,Aug 15;90(16):7769-73.

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药学学报
2002年 第9期

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