糖尿病肾病临床期老龄患者实施前列地尔序贯治疗的效果观察

Observation on the Effect of Sequential Treatment of Senile Patients with Diabetic Nephropathy in Clinical Stage

目的观察糖尿病肾病临床期老龄患者实施前列地尔序贯治疗的效果。方法在2017年1月至2018年3月,纳入160例糖尿病肾病临床期患者参加本研究。随机分为对照组和观察组。两组患者实施常规治疗。并静脉滴注前列地尔。观察组联用口服贝前列腺素钠。治疗前后检测24 h蛋白定量(U-TP)、尿微量白蛋白(mALB)、尿蛋白排泄量。观察治疗过程中发生不良反应的情况。结果治疗后两组U-TP、mALB、尿蛋白排泄量均低于治疗前,P<0.05;且观察组U-TP、mALB、尿蛋白排泄量低于对照组,P<0.05。两组不良反应发生率相比,P>0.05。结论糖尿病肾病临床期老龄患者实施前列地尔序贯治疗可起到很好的效果,不易引发不良反应。

Objective to observe the effect of sequential therapy on elderly patients with diabetic nephropathy. Methods from January 2017 to March 2018, 160 patients with diabetic nephropathy were enrolled in this study. These patients were randomly divided into a control group and an observation group.Two groups of patients were treated routinely.And intravenous drip of alprostadil.The observation group was treated with oral betaproen sodium. 24-hour protein quantification（u-tp）, urinary albumin（mALB） and urinary protein excretion were detected before and after treatment. The adverse reactions during the treatment were observed. Results after treatment, u-tp, mALB and urinary protein were all lower than those before treatment, P〈0.05.In addition, u-tp, mALB and urinary protein excretion in the observation group were lower than those in the control group, P〈0.05.The incidence rate of adverse reactions was compared between the two groups, P〉0.05. Conclusion the sequential therapy of alprostadil in elderly patients with diabetic nephropathy is effective in preventing adverse reactions.