治疗痤疮外用中药专利用药规律分析

Analysis of Administration Rules of Patented Externally-used Chinese Herbal Medicine for Acne

目的:研究治疗痤疮外用中药专利的用药规律。方法:通过中国知网专利数据库高级检索输入"痤疮"或"粉刺"和"中药"或"中成药",检索专利名称,共得到487条相关专利,其中146条为外用专利,运用频数分析、聚类分析的统计学方法对这些外用中药专利用药规律进行归纳分析,并研究治疗痤疮外用中药专利核心药物的组成、功效、药物配伍等。结果:治疗痤疮外用中药专利使用频率前20名的药物为:白芷、菊花、黄芩、甘草、金银花、冰片、黄连、丹参、连翘、苦参、蒲公英、黄柏、当归、茯苓、大黄、白附子、芦荟、三七、珍珠、防风。排名前20名的药物使用频数在功效作用方面分类情况:清热药225次,频数最高,占总频数的44.20%;其次为解表药62次,占总频数的12.18%;攻下药36次,占总频数7.07%。在归经方面分类情况:胃经,共308次,占总频数18.17%;心经,共298次,占总频数17.58%;肝经,共235次,占总频数13.86%;脾经,共204次,占总频数12.04%。结论:从用药类型和用药频数可推断出痤疮的病因病机主要与风热、湿热、瘀血、痰凝等因素相关,这与我们原来所认识的痤疮病因病机风热外袭、肺胃湿热、痰瘀互结基本一致,体现了治疗痤疮外用中药专利的用药是临证用药的选择,在痤疮临床外用药治疗和新药开发方面,均具有一定的参考价值。

Objective： To study the administration rules of patented externally-used Chinese herbal medicine for acne. Methods：Entered ＂ acne＂, ＂ Chinese herbal medicine＂ or ＂ Chinese patent medicine＂ through the advanced search of patent database of CNKI,searched the patent name,and got a total of 487 related patents including 146 externally-used Chinese herbal medicines. Used the statistical methods like frequency analysis and cluster analysis to summarize and analyze the administration rules of these patented externally-used Chinese herbal medicine. Studied the composition,efficacy and medicine compatibility of patented externally-used core Chinese herbal medicine for acne. Results：The top 20 patented Chinese herbal medicine for acne are Radix Angelicae Dahuricae,Flos Chrysanthemi, Radix Scutellariae, Radix et Rhizoma Glycyrrhizae, Flos Lonicerae Japonicae, Borneolum Syntheticum, Rhizoma Coptidis, Radix et Rhizoma Salviae Miltiorrhizae, Fructus Forsythiae, Radix Sophorae Flavescentis, Herba Taraxaci, Cortex Phellodendri Chinensis, Radix Angelicae Sinensis, Poria, Radix et Rhizoma Rhei, Rhizoma Typhonii, Aloe, Radix et Rhizoma Notoginseng, and Radix Saposhnikoviae. The top 20 Chinese herbal medicine use frequencies are classified as follows in terms of efficacy：225 times of heat-clearing medicine（44.20%）,62 times of exterior-releasing medicine（12.18%）,and 36 times of purgative medicine（7.07%）. The top 20 Chinese herbal medicine use frequencies are classified as follows in terms of meridian tropism：308 times of the stomach meridian（18.17%）,298 times of the heart meridian（17.58%）,235 times of the liver meridian（13.86%）and 204 times of the spleen meridian（12.04%）. Conclusion： It can be concluded that the etiology and pathogenesis of acne are mainly related to wind-heat,dampness-heat,blood stasis and coagulated phlegm from the medication types of Chinese herbal medicine and medication frequency. This is basically consistent with the original understanding of the etiology and pathogenesis of acne as the external attack of wind-heat,dampness-heat of the lung and the stomach,and phlegm and blood stasis. It shows that the patented externally-used Chinese herbal medicine for acne is the choice of clinical medicine, which has certain reference value in the treatment of acne and the development of new medicine.